As we emerge in a post-pandemic society, the feelings of isolation present during quarantine persist. But for some, these feelings of isolation have been present long before the pandemic began. The ideal of mental wellness is an important one: depression, anxiety, and persistent feelings of hopelessness severely impact our lives, relationships with loved ones, and our relationship with ourselves. In conjunction with an understanding of mental wellness, there must also be an understanding of mental illness. For in our pursuit of mental wellness after quarantine, we must not forget our compassion for those who have been suffering without. Through this short virtual issue, we invite you to read the following selected articles from Culture & Psychology. Thematically, they may find themselves fitting well with a weekly seminar, or a graduate course on mental health. One may find themselves discovering new insights of theoretical expansion beyond what this Special Issue can provide. Thus, in a quest for the solidification of our compassion, this virtual issue delves into three key aspects of depression: its relationship with ourselves, our cultures, and our bodies.