Describing bladder storage function: overactive bladder syndrome and detrusor overactivity

Abrams, Paul

doi:10.1016/j.urology.2003.09.050

Cited by 233 publications

(166 citation statements)

References 15 publications

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“…14 It is known to cause great discomfort, affecting the lives of many women, but it also affects men. 2 Strong associations between obesity and both urinary and fecal incontinence have been reported. 15,16 According to the Clinical Guidelines on the Identification, Evaluation and Treatment of Overweight and Obesity in Adults, from the National Institutes of Health, (National Heart, Lung and Blood Institute), about 97 million adults are overweight or obese in the United States.…”

Section: Resultsmentioning

confidence: 99%

“…OAB is defined by the International Continence Society (ICS) as urinary urgency, with or without urgency incontinence and frequently associated with increase of frequency and noctúria. 2 It has been suggested that OAB incidence is not related to age; 3,4 many women who are young and active have their lives limited due to discomfort caused by OAB.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Palma¹,

Raimondi²,

Souto³

et al. 2014

Rev. Assoc. Med. Bras.

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Correlation between body mass index and overaCtive bladder symptoms in pre-menopausal women rev assoC med bras 2014; 60 (2) Conflict of interest: noneObjective: The aim of the study was to establish a correlation between Overactive Bladder (OAB) symptoms and Body Mass Index (BMI) in women aged 20-45. Methods: We interviewed 1.050 women aged 20-45 in the area of Campinas, Brazil, to investigate the prevalence of overactive bladder symptoms. In this study, we used the ICIQ-OAB questionnaire (ICS standard), in its validated portuguese version and a specific questionnaire for the demographics, which includes information about BMI. Results: Overall, women with BMI ≥30 presented a significantly higher score than women with a lower BMI (18.5 -24.9) (p=0.0066). In the analysis of individual symptoms, no significant differences were found regarding urinary frequency (p=0.5469). Women with BMI ≥30 presented more nocturia than women with BMI ranging between 18.5 and 24.9 (p=0.0154). Women in the group of BMI 25 -29.9 presented more urgency than women with BMI 18.5 -24.9 (p=0.0278). Significant difference was also found regarding urge-incontinence; women with BMI 25 -29.9 presented a higher score than women in the group 18.5 -24.9 (p= 0.0017). Analysis was also performed on the visual analogue scale regarding how much each symptom bothers the women (quality of life). There were no significant differences regarding frequency, nocturia or urgency but urgency incontinence bother was significant. Women with BMI 25 -29.9 were more bothered by incontinence than women with BMI 18.5 -24.9 (p=0.002). Conclusion:In conclusion, this study reinforces the correlation between BMI and OAB symptoms. Obese women present more OAB symptoms than non-obese women.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Palma¹,

Raimondi²,

Souto³

et al. 2014

Rev. Assoc. Med. Bras.

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“…Overactive bladder (OAB) is a symptom complex characterised by an increase of the frequency 45 of micturition and feelings of urgency, accompanied sometimes by incontinence [1]. It is a highly 46 prevalent disorder, especially in the elderly and women[2;3], has a profound impact on the 47 quality of life [4;5], and is economically very burdensome to health providers [6].…”

Section: Introduction 43 44mentioning

confidence: 99%

Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders

et al. 2009

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“…bFGF; bladder smooth muscle cell; connexin 43; ERK; hypersensitivity OVERACTIVE BLADDER IS A HIGHLY prevalent clinical condition that is characterized by urgency and urinary frequency (1,27,41,43). The etiology of bladder overactivity is diverse, including impaired innervation, inflammation, or bladder outlet obstruction (BOO) (27,43).…”

mentioning

confidence: 99%

Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle

Imamura¹,

Negoro²,

Kanematsu³

et al. 2009

American Journal of Physiology-Renal Physiology

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Overactive bladder is a highly prevalent clinical condition that is often caused by bladder outlet obstruction (BOO). Increased coupling of bladder smooth muscle cells (BSMC) via gap junctions has been hypothesized as a mechanism for myogenic bladder overactivity in BOO, although little is known about the regulatory system underlying such changes. Here, we report the involvement of basic fibroblast growth factor (bFGF) and connexin 43, a bladder gap junction protein, in bladder overactivity. BOO created by urethral constriction in rats resulted in elevated bFGF and connexin 43 levels in the bladder urothelium and muscle layer, respectively, and muscle strips from these bladders were more sensitive than those from sham-operated controls to a cholinergic agonist. In vitro bFGF treatment increased connexin 43 expression in cultured rat BSMC via the ERK 1/2 pathway. This finding was supported by another in vivo model, where bFGF released from gelatin hydrogels fixed on rat bladder walls caused connexin 43 upregulation and gap junction formation in the muscle layer. Bladder muscle strips in this model showed increased sensitivity to a cholinergic agonist that was blocked by inhibition of gap junction function with α-glycyrrhetinic acid. Cystometric analyses of this model showed typical features of detrusor overactivity such as significantly increased micturition frequency and decreased bladder capacity. These findings suggest that bFGF from the urothelium could induce bladder hypersensitivity to acetylcholine via gap junction generation in the smooth muscle, thereby contributing to the myogenic overactivity of obstructed bladders.

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Describing bladder storage function: overactive bladder syndrome and detrusor overactivity

Cited by 233 publications

References 15 publications

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders

Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle

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