Desacetyl vinblastine amide sulfate induced ineffective erythropoiesis

Abstract

Ineffective erythropoiesis occurred during desacetyl vinblastine amide sulfate (VDS) therapy of a patient with metastatic Ewing's sarcoma. The peripheral blood was characterized by anisocytosis, poikilocytosis and reticulocytopenia. Bone marrow showed megaloblastic red cell hyperplasia with nuclear fragmentation, binuclearity and abnormal metaphases. Radioiron incorporation into red cells was markedly decreased. Electron microscopy showed red cell surface changes previously called ropalocytosis. Normal erythropoiesis promptly resumed when VDS treatment was withheld. Although less common than leukopenia, red cell abnormalities are part of the spectrum of vinca alkaloid toxicity.

Comparison between hematological and biochemical changes caused by conventional and metronomic chemotherapies in the treatment of canine transmissible venereal tumor

“…In addition to the total erythrocyte count in dogs affected by TVT, the RDW tends to remain within the reference values without showing an increase in cell diameter, characteristic of young cells due to spinal cord regeneration. Even during the post-treatment period, chemotherapeutic agents may act by suppressing erythropoiesis in the BM (Jumean et al 1979, Yadav et al 2018.…”

Vindesine Sulfate

“…1 4 Damage to the erythrocytes from vindesine sulfate is usually minimal, although a recent case report describes anemia due to ineffective erythropoiesis that required blood transfusions in a patient receiving weekly vindesine sulfate therapy. 16 =2=…”