Precise assessment of facial lesions in photo-damaged skin could be challenging. A collision of benign, premalignant and malignant tumours is not uncommon. Selecting the biopsy site is fundamental for making a proper diagnosis. Therefore, biopsies should not be taken blindly but should be preceded by a detailed preliminary evaluation with dermoscopy, in particular. The article presents a case of a 78-year-old female patient, in whom dermoscopy-guided incisional biopsy of an irregular erythematous plaque led to the diagnosis of in situ squamous cell carcinoma.