Orofacial granulomatosis is a nonspecific term that contains a wide variety of
granulomatous entities, which share a clinical and histopathological
presentation. It manifests as persistent or recurrent orofacial swelling,
amongst other findings. Idiopathic orofacial granulomatosis, characterized by an
absence of systemic granulomatous disease, is a diagnosis of exclusion. The main
differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however,
it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is
well documented. Currently, therapeutic options consider restrictive diets,
topical, intralesional, and systemic agents. First-line therapy is currently a
matter of debate. We present a review of the value of diet therapy in this
syndrome, along with two illustrative cases.
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