Dermoscopy of Microvenular Hemangioma: Report of a Case

Scalvenzi, Massimiliano; Natale, Flora De; Francia, Maria Grazia; Balato, Anna

doi:10.1159/000102038

Cited by 19 publications

(14 citation statements)

References 24 publications

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“…The second most common pattern was composed of a reddish-violaceous or reddish-brown homogeneous area that occupied the whole lesion, most often with vascular and white structures, found in 8 cases (22.8%). This pattern has also been described to be rarely associated with some vascular tumors (microvenular hemangioma [11] and retiform hemangioendothelioma [12], to name a few), aneurysmatic dermatofibromas [13], purpuric dermatosis [14], and some amelanotic melanomas [15,16]. Menzies et al [15] found that some of the most positive predictors of amelanotic or hypomelanotic melanomas were irregularly shaped depigmentation (white structures), the presence of more than one shade of pink (reddish homogeneous pigmentation), and peripheral light brown structureless areas (reddish-brown homogeneous areas), and therefore nontargetoid THH can be considered a mimic of melanoma [7,15].…”

Section: Discussionmentioning

confidence: 89%

Dermoscopy of Targetoid Hemosiderotic Hemangioma: A Morphological Study of 35 Cases

et al. 2015

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Background: Targetoid hemosiderotic hemangioma is an uncommon, vascular, benign solitary lesion of lymphatic origin that can be misdiagnosed as other tumors including melanomas. Objectives: To evaluate the dermoscopic features of a large series of targetoid hemosiderotic hemangiomas. Methods: Digital dermoscopic images of 35 histopathologically confirmed cases of targetoid hemosiderotic hemangiomas collected from 7 hospitals in Spain and Italy were evaluated for the presence of dermoscopic structures and patterns. Results: The results of our study reveal that the presence of central red and dark lacunae and a peripheral circular reddish-violaceous homogeneous area is the most common dermoscopic pattern in targetoid hemosiderotic hemangioma (71.4%). The targetoid hemosiderotic hemangiomas of our study were correctly diagnosed in 77% of cases. Conclusion: Dermoscopy is helpful in improving the diagnosis of targetoid hemosiderotic hemangioma. However, attention must be paid to those cases that dermoscopically may show nontargetoid patterns, which often mimic other lesions, including melanoma.

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Section: Discussionmentioning

confidence: 89%

Dermoscopy of Targetoid Hemosiderotic Hemangioma: A Morphological Study of 35 Cases

et al. 2015

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“…By dermoscopy, MVH shows diffuse erythema with multiple well-demarcated small red globules, varied in size, and a fine pigment network at the periphery. 16 MVH has not been reported to recur after excision. 2,[6][7][8]11,14 Untreated solitary 18,19 and multiple MVHs 2,22 and treated (pulse dye laser) multiple MVH 23 are persistent lesions.…”

Section: Discussionmentioning

confidence: 89%

“…Table 1 summarizes the clinical profile of the 40 cases of MVH reported to date. 1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In general, MVH is a rare, acquired, benign vascular neoplasm that presents as a solitary, enlarging or asymptomatic, small purple to red papule or nodule in young to middle-aged adults with a predilection for the trunk and lower extremities. By dermoscopy, MVH shows diffuse erythema with multiple well-demarcated small red globules, varied in size, and a fine pigment network at the periphery.…”

Section: Discussionmentioning

confidence: 99%

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Linos

Csaposs²

2013

The American Journal of Dermatopathology

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Microvenular hemangioma (MVH) is a rare, slowly growing, benign vascular tumor that typically presents as a solitary enlarging plaque or nodule on the trunk or the extremities of young to middle-aged adults. A minority of MVH present with multiple lesions that are either gradually or suddenly acquired (eruptive MVH). Herein, we report a case of a 53-year-old woman who progressively developed numerous bilateral MVHs presenting as enlarging, blanching, erythematous to violaceous macules, patches, and plaques over the proximal thighs and axillae. Two biopsies exhibited the irregular branching venules with inconspicuous lumina lacking endothelial atypia and associated with dermal fibrosis characteristic of MVH. Immunophenotypically, the endothelium expressed Wilms Tumor 1, CD31, CD34, and erythrocyte-type glucose transporter protein (GLUT-1) GLUT-1 focally and was negative for Human herpes virus 8 and the lymphatic marker D2-40. In addition, numerous dermal spindle cells expressing CD34 and procollagen, putative fibrocytes, surrounded the thickened dermal collagen bundles and small vessels of MVH implicating a reactive/reparative (proliferative) process due to an unrecognized cutaneous injury. A review of MVH summarizing its clinicopathologic findings and its natural history is presented.

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“…Upon dermoscopic examination, multiple well-demarcated red globules are observed with the presence of a fine pigmented network at the periphery (9). Histologically, MH is composed of thin-walled, irregularly branching venules with inconspicuous vascular lumina.…”

Section: Discussionmentioning

confidence: 99%

“…The endothelial cells are surrounded by pericytes (10) and may present as a mixture of flat or plump cells, but with a lack of cellular atypia, pleomorphism or mitotic figures (11). Immunohistochemically, the endothelial cells of an MH are positive for CD31, CD34 and factor VIII, and the pericytes are positive for SMA (9,12), but both stain negative for podoplanin (13). …”

Section: Discussionmentioning

confidence: 99%

Multiple microvenular hemangioma: A case report

Jindal

et al. 2013

Oncology Letters

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The current study reports a case of multiple microvenular hemangioma (MH). A 35-year-old male presented with dark red maculopapules on the trunk and limbs that had been apparent for 5 years. The number of lesions exceeded 100 in total. A histological examination demonstrated multiple, irregular, branching venules in the dermis, without any endothelial atypia. On immunohistochemical analysis of the vascular structures, the endothelial cells stained positive for CD31, CD34 and factor VIII, and the perivascular cells stained positive for SMA and HHF-35. These observations were consistent with a diagnosis of MH, and should be differentiated from the most common differential diagnosis of patch-stage Kaposi’s sarcoma. There was no clear effect following topical application of recombinant human interferon α-2b gel.

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Dermoscopy of Microvenular Hemangioma: Report of a Case

Cited by 19 publications

References 24 publications

Dermoscopy of Targetoid Hemosiderotic Hemangioma: A Morphological Study of 35 Cases

Dermoscopy of Targetoid Hemosiderotic Hemangioma: A Morphological Study of 35 Cases

Microvenular Hemangioma Presenting With Numerous Bilateral Macules, Patches, and Plaques

Multiple microvenular hemangioma: A case report

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