Dermoscopy of Cutaneous Lymphoproliferative Disorders: Where Are We Now?

Abstract

The prompt identification of cutaneous lymphoproliferative disorders (CLD) has always been a challenge in dermatological practice, due to the rarity of this group of diseases, the heterogeneity in clinical presentation, and plenty of variants described in the literature so far. The strict cooperation between dermatologist and pathologist is the key element for the correct diagnosis of CLD deriving from the perfect integration of clinical and histopathological features. In this complex context, dermoscopy could play an adjuvant role in the achievement of the diagnosis, as it fits itself as the third diagnostic tool in the paraphernalia of the dermatologist between the clinical and histopathological examination. This review provides the state of art of dermoscopy of CLD.

Dermoscopy of primary cutaneous B‐ and T‐cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case‐control study with histopathologic correlation

“…The up‐to‐date literature on the dermoscopic features of PCL includes mostly case reports and small case‐series . Larger studies on PCL dermoscopy are almost always descriptive, characterizing the dermoscopic features in either primary cutaneous B‐cell lymphomas or in early stage mycosis fungoides with patch or plaque lesions only .…”

Angiomatoid nodule of the breast

“…Most cases of PG have red lacunae associated with white rail lines (WRLs) and occasionally a white collarette [7]. Dermatoscopy of TRAPP has not yet been reported in the literature, although data regarding dermatoscopy of cutaneous pseudolymphoma have been published, showing as predominant features the combination of white reticular lines, a pinkish background and fine linear vessels [8]. In our patient, none of the above-mentioned features was recognizable except for linear vessels that were detectable at the periphery.…”

An enlarging scaly plaque localized on the previous keloid of the chest

“…Digital dermoscopic examination with FotoFinder HD 1000 findings were follicular keratinization and plugging, yellow dots and scales, reticulated and linear blood vessels, multiple discrete ulcers, an elongated white fibrous band (Figure ). Considering Piccolo's and colleagues' review, these dermoscopic signs are in favor of a lymphoproliferative disorder, especially mycosis fungoides …”

“…Considering Piccolo's and colleagues' review, these dermoscopic signs are in favor of a lymphoproliferative disorder, especially mycosis fungoides. 2 Skin biopsy was performed, with a differential diagnosis of cutaneous T-cell lymphoma (mycosis fungoides, pagetoid reticulosis), seborrheic dermatosis, Bowen's disease, keloid, and psoriasis. The biopsy specimen revealed a lymphoproliferative disorder with epidermotropism.…”