Dermoscopy and the Diagnostic Challenge of Amelanotic and Hypomelanotic Melanoma

Stoecker, William V.

doi:10.1001/archderm.144.9.1207

Cited by 28 publications

(32 citation statements)

References 30 publications

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“…These patterns were usually combined with additional (one to two) vascular features. These findings reinforce the impression that MCC should be considered as a dermoscopic differential diagnosis of amelanotic presentations of melanoma including desmoplastic melanoma [10,11,12,13,14,15,16,17,18,19]. …”

Section: Discussionsupporting

confidence: 78%

Dermoscopy of Merkel Cell Carcinoma

et al. 2012

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Introduction: Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor whose clinical presentation, usually a pink nodule, is not specific. We aimed in this study to determine the dermoscopic criteria encountered in MCC. Methods: From our image database we selected the patients diagnosed with MCC and scored the dermoscopic criteria shown by these tumors. Results: Ten patients coming from three different academic hospitals were studied. Vascular structures were the more relevant dermoscopic features. In 8 out of 10 (80%) patients a polymorphic vascular pattern was seen, composed of milky-red clods/areas in association with one or more additional vascular structures. Conclusion: Although an overlap existed between the dermoscopic features observed in MCC and amelanotic melanoma, the presence of a polymorphous vascular pattern may constitute an additional clinical clue to accurately diagnose this rare tumor.

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Section: Discussionsupporting

confidence: 78%

Dermoscopy of Merkel Cell Carcinoma

et al. 2012

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“…In only one of such nine cases, the polymorphous vascular pattern was due to the combination of arborizing, hairpin, glomerular, linear irregular and dotted vessels in the absence of any other dermoscopic feature. Polymorphous vessels are usually detected in amelanotic ⁄ hypomelanotic melanoma 7,12,13 and in squamous cell carcinoma 7,14 and are correlated with angiogenesis of these tumours.…”

Section: Discussionmentioning

confidence: 99%

Vascular patterns in basal cell carcinoma

Micantonio¹,

Gulia²,

Altobelli

et al. 2011

Acad Dermatol Venereol

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“…AMs can also appear as erythematous scaly eczema-like patches, nonhealing ulcers or hyperkeratotic warts, the latter being misdiagnosed for tinea or onychomycosis. The correct diagnosis of AMs depends critically on vascular patterns, which are visible only using dermoscopy [1][2][3][4][5]. Microscopically, they are often classified as nodular melanomas, with a high Breslow thickness and significant mitotic activity, and it has been suggested that this rapidly growing melanoma subtype [6] may have an intrinsically more aggressive biological behavior in comparison with conventional pigmented melanomas [7].…”

Section: Introductionmentioning

confidence: 99%

BRAF and KIT somatic mutations are present in amelanotic melanoma

Massi

Pinzani²,

Simi³

et al. 2013

Melanoma Research

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The genotypic profile of rare amelanotic melanomas (AMs) has been poorly investigated, thus preventing either an accurate identification as a distinctive melanoma subtype or therapy stratification. Here, we investigated the presence of the BRAF(V600E) mutation by real-time quantitative PCR and KIT mutations (exons 11 and 17) by sequencing analysis in 33 AMs. AMs included 'truly' amelanotic lesions (n = 19), with no melanin pigmentation upon dermoscopic inspection and hypomelanotic lesions (n = 14), by definition partially pigmented lesions showing a melanin pigmentation area of less than 25% of the total surface area. The frequency of the BRAF(V600E) mutation was 70.3% in the 33 cases, a percentage that increased to 89% when only the subgroup of thin melanomas (≤ 1 mm in thickness, n = 9) was considered. KIT mutations were found in 12.1% of AMs, all of which developed in nonacral sites. The identification of a relatively high frequency of BRAF(V600E) and KIT mutations in AMs may have important consequences for implementation of the novel targeted therapies now available to treat this life-threatening disease.

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Dermoscopy and the Diagnostic Challenge of Amelanotic and Hypomelanotic Melanoma

Cited by 28 publications

References 30 publications

Dermoscopy of Merkel Cell Carcinoma

Dermoscopy of Merkel Cell Carcinoma

Vascular patterns in basal cell carcinoma

BRAF and KIT somatic mutations are present in amelanotic melanoma

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