Dermoscopic Findings of Alopecia in Patients with Hypothyroidism

Nejad, Kaveh Gharaei; Motamed, Behrang; Rad, Afagh Hassanzadeh; Rafiee, Elahe; Dalili, Setila; Molaei, Atrie

doi:10.5812/ijem-128938

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…As a result, worldwide screening strategies must be implemented effectively. Unless hypothyroidism is treated, it may result in greater physical changes over time (19,(38)(39)(40)(41)(42).…”

Section: Main Clinical Manifestationsmentioning

confidence: 99%

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Koohmanaee,

Bakhshi,

Pourkazem

et al. 2023

J Compr Ped

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Context: Hypothyroidism describes an endocrine disorder that occurs when the thyroid gland cannot secrete adequate thyroid hormones. Congenital hypothyroidism refers to a lack of thyroid hormone among newborns. Evidence Acquisition: The ISI Web of Sciences, Scopus, PubMed, and Google Scholar databases were reviewed for relevant articles published from 2000 to 2022. Results: Congenital hypothyroidism, occurring in approximately one in 2,000 to one in 4,000 newborns, ranks among the most frequent causes of intellectual disability that can be prevented. The screening of newborns, confirmation assessments, interpretation of thyroid function tests accurately, prompt and therapeutic treatment, and regular follow-up contribute to a very good neurocognitive outcome later in life. Since the timely diagnosis of congenital hypothyroidism is critical in preventing mental retardation, clinicians must be kept abreast of this disorder and educate nursing and medical students regarding accurate interpretations of diagnostic testing and the recognition of associated symptoms. Most newborns with congenital hypothyroidism present no symptoms, even though their TSH or T4 levels are likely to have fluctuated significantly. As a result, congenital hypothyroidism was rarely detected in newborns before the introduction of neonatal screenings. Conclusions: We provide an overview of the etiology, epidemiology, manifestation, diagnosis, and treatment of congenital hypothyroidism based on the latest studies.

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Section: Main Clinical Manifestationsmentioning

confidence: 99%

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Koohmanaee,

Bakhshi,

Pourkazem

et al. 2023

J Compr Ped

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“…Clinically, thyroid hormones (THs), namely triiodothyronine (T3) and L-thyroxine (T4), have long been appreciated as endocrine mediators whose serum levels potently affect human hair growth and hair shaft quality (van Beek et al 2008;Gharaei Nejad et al 2022;Hussein et al 2023). Yet, THs remain to be systematically explored as a candidate for hair growth-modulatory therapeutics in dermatology (Hussein et al 2023;Paus et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin

Gherardini,

Akhundlu,

Gompels

et al. 2024

Preprint

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We have previously shown that the thyroid hormones triiodothyronine (T3) and thyroxine (T4) prolong anagen, mitigate stem cell apoptosis, and stimulate mitochondrial functions in microdissected human scalp HFs ex vivo. To circumvent the systemic adverse effects of T3/T4, we have asked in the current pilot study whether topically applied T3/T4 retains hair growth-promoting properties. To prove this, we have topically treated healthy full-thickness human scalp skin with T3 (1, 10nM) and T4 (1, 10μM) for six days in serum-free organ culture, using an HF-targeting vehicle that contains only FDA-approved ingredients. This showed that, at distinct doses, topical T3 and T4 significantly increased the percentage of HFs in anagen, decreased the percentage of proliferative (Ki-67+) cells in the hair matrix, did not promote melanogenesis (as measured by quantitative Warthin-Starry histochemistry), and significantly increased keratin 15 expression in the bulge. Finally, T3 and T4, at low concentrations, increase the expression of the hair growth promoters IGF-1 and FGF-7. The lower concentration of T3 and both of T4 also significantly increases the number of CD31+ endothelial cells, suggesting a pro-angiogenic effect, which is also important for hair growth promotion. These preliminary results strongly suggest that topically applied thyroid hormones promote hair growth in intact human scalp on multiple levels ex vivo. This invites the intermittent pulse application of topical T3 and T4 as a novel therapeutic intervention for managing hair loss disorders associated with telogen effluvium, such as androgenetic alopecia.

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“…4 Recent studies have shown an association between LPP and alopecia as well as some underlying diseases such as Hashimoto thyroiditis, hypothyroidism, hirsutism, vitamin D deficiency, allergic rhinitis, type 2 diabetes mellitus, hyperlipidemia, and depression. [5][6] Vitamin D is important in regulation of the genes involved in hair growth. One study showed that the serum vitamin D concentration was significantly lower in the alopecia areata group than in the control group.…”

Section: Introductionmentioning

confidence: 99%

Most Frequent Comorbidities in Patients With Lichen Planopilaris: A Cross-Sectional Study

Nejad

Ghadarjani

Eftekhari

et al. 2023

International Journal of Dermatology and Venereology

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Objective: Lichen planopilaris (LPP) is a rare skin disorder, but it is also the most common cause of scarring alopecia in adults. The main cause of this disease is unknown, but it is considered to be related to the immune status of the body. Several comorbidities are reportedly associated with LPP, such as hypertension, depression, thyroiditis, diabetes, and vitiligo. In the present study, we aimed to investigate the frequency of comorbidities in patients with LPP who were referred to Razi Hospital in Rasht, Iran, from 2016 to 2019.Methods: This cross-sectional study involved 60 patients with cicatricial alopecia patches (scarring and irreversible) and clinical signs and symptoms consistent with active LPP. The association between demographic data and comorbidities in patients with LPP was evaluated with the chi-square test and t test. Results:The results showed that the most common comorbidities were vitamin D deficiency (24.3%), hypothyroidism (17.6%), anemia (16.2%), asthma and allergy (14.8%), hypertension (13.5%), diabetes (9.5%), and vitiligo (4.5%). There was no statistically significant association of sex, age, or body mass index with LPP according to the presence or absence of underlying disease (P = 0.440, P = 0.108, and P = 0.340, respectively); however, there was a statistically significant difference in the presence of comorbidities according to age (P = 0.018). Conclusion:The results illustrated that women with vitamin D deficiency are more prone to LPP than are patients with other pre-existing underlying diseases.

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Dermoscopic Findings of Alopecia in Patients with Hypothyroidism

Cited by 3 publications

References 19 publications

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Diagnosis and Management of Congenital Hypothyroidism: An Updated Overview

Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin

Most Frequent Comorbidities in Patients With Lichen Planopilaris: A Cross-Sectional Study

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