Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin
Jennifer Gherardini,
Aysun Akhundlu,
Matthew Gompels
et al.
Abstract:We have previously shown that the thyroid hormones triiodothyronine (T3) and thyroxine (T4) prolong anagen, mitigate stem cell apoptosis, and stimulate mitochondrial functions in microdissected human scalp HFs ex vivo. To circumvent the systemic adverse effects of T3/T4, we have asked in the current pilot study whether topically applied T3/T4 retains hair growth-promoting properties. To prove this, we have topically treated healthy full-thickness human scalp skin with T3 (1, 10nM) and T4 (1, 10μM) for six days… Show more
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