Dermopathic Changes in Hypozincemia

Abou-Mourad, Naji N.; Farah, Fuad S.; Steel, Dinah

doi:10.1001/archderm.1979.04010080020014

Cited by 10 publications

(3 citation statements)

References 17 publications

(2 reference statements)

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“…The role of zinc in the rare congenital skin disease acrodermatitis enteropathica is well known to dermatologists 1,31 though few will have ever seen an actual case in clinical practice. The clinical manifestations associated with zinc deficiency arise primarily from the cutaneous changes similar to those found in acrodermatitis enteropathica 32 …”

Section: Scaling Problems and Hair Loss: Is There A Nutritional Basis?mentioning

confidence: 99%

Nutritional factors and hair loss

Rushton

2002

Clinical and Experimental Dermatology

259

185

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The literature reveals what little is known about nutritional factors and hair loss. What we do know emanates from studies in protein-energy malnutrition, starvation, and eating disorders. In otherwise healthy individuals, nutritional factors appear to play a role in subjects with persistent increased hair shedding. Hård, 40 years ago, demonstrated the importance of iron supplements in nonanaemic, iron-deficient women with hair loss. Serum ferritin concentrations provide a good assessment of an individual's iron status. Rushton et al. first published data showing that serum ferritin concentrations were a factor in female hair loss and, 10 years later, Kantor et al. confirmed this association. What level of serum ferritin to employ in subjects with increased hair shedding is yet to be definitively established but 70 micro g/L, with a normal erythrocyte sedimentation rate (< 10 mm/h), is recommended. The role of the essential amino acid, l-lysine in hair loss also appears to be important. Double-blind data confirmed the findings of an open study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron therapy. There is no evidence to support the popular view that low serum zinc concentrations cause hair loss. Excessive intakes of nutritional supplements may actually cause hair loss and are not recommended in the absence of a proven deficiency. While nutritional factors affect the hair directly, one should not forget that they also affect the skin. In the management of subjects with hair loss, eliminating scaling problems is important as is good hair care advice and the need to explain fully the hair cycle. Many individuals reduced their shampooing frequency due to fear of losing more hair but this increases the amount seen in subsequent shampoos fuelling their fear of going bald and adversely affecting their quality of life.

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Section: Scaling Problems and Hair Loss: Is There A Nutritional Basis?mentioning

confidence: 99%

Nutritional factors and hair loss

Rushton

2002

Clinical and Experimental Dermatology

259

185

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“…Die Bedeutung von Zink bei der seltenen kongenitalen Hauterkrankung Acrodermatitis enteropathica (AE) ist Dermatologen bekannt (1, 31), auch wenn nur wenige im klinischen Alltag einen betroffenen Patienten gesehen haben. Das klinische Bild, welches mit einem Zinkmangel assoziiert ist, ähnelt im Prinzip den kutanen Veränderungen bei AE (32).…”

Section: Schuppenbildung Und Haarausfall; Hat Die Ernährung Einfluss?unclassified

Ernährung und Haarausfall

Rushton

2002

H G Z Hautkrankh

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Zusammenfassung: Die vorliegende Literatur zeigt, wie wenig u È ber Erna È hrungsfaktoren und Haarausfall bekannt ist. Das vorhandene Wissen resultiert aus Untersuchungen zur Protein-Mangelerna È hrung, zu Hungerzusta È nden und Esssto È rungen. Bei ansonsten gesunden Menschen scheinen bei anhaltendem, vermehrten Haarausfall Erna È hrungsfaktoren eine Rolle zu spielen. Bereits vor 40 Jahren demonstrierte Ha Ê rd, wie wichtig eine Eisensubstitution bei nicht-ana È mischen Frauen mit Haarausfall und Eisenmangel ist. Die Serum-Ferritinspiegel erlauben einen guten Einblick in den Eisenstatus eines Patienten. Rushton et al. vero È ffentlichten erstmals Daten, die verdeutlichten, dass die Bestimmung der Serum-Ferritinspiegel beim weiblichen Haarausfall wichtig ist und 10 Jahre spa È ter besta È tigten Kantor et al. diesen Zusammenhang. In welchem Bereich sich der Serum-Ferritin-Spiegel bei Personen mit versta È rktem Haarausfall bewegen sollte, muss nun definitiv bestimmt werden, doch wird der Wert bei normaler BSG (Blutsenkungsgeschwindigkeit, NW: < 10 mm/h) ungefa Èhr bei 70 mg/l liegen. Auch die essentielle Aminosa È ure L-Lysin scheint beim Haarausfall relevant zu sein. Eine Doppelblind-Studie besta È tigte die Ergebnisse einer offenen Studie an Frauen mit vermehrtem Haarausfall, von denen viele gut auf die Gabe von L-Lysin und Eisensubstitution reagierten. Es gibt keine Beweise fu È r die verbreitete Meinung, dass niedrige Z Hautkr 2002; 77, 359±366 359 Rubrik ã Zeitschrift fu Èr Hautkrankheiten, H+G (77) 359±366 (

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“…The clinical features of the se patients were very similar to the so-called 'parakeratosis of the pig', a zinc deficiency state of the pig [38], and to acrodermatitis enteropathica (AE), which is at present considered as a congenital zinc deficiency syndrome [4] probably caused by a congenital defect in the absorption of zinc [21] and curable with the administration of zinc salts [24,26], There are other reports of acrodermatitis enteropathica-like syndromes, caused by lack of administration of zinc supplements in patients on TPA [1,2,6,7,28,39,41,45,50]. Only a few cases of acquired zinc deficiency not caused by a TPA regimen devoid of zinc have been reported [9,23,46].…”

Section: Introductionmentioning

confidence: 99%

Acquired Zinc Deficiency Syndrome during Total Parenteral Alimentation

et al. 1981

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An acute zinc deficiency state developed in 6 patients on total parenteral alimentation, which allegedly included zinc 37 μmol/l. The actual concentration of this trace element when measured by us, was 3 μmol/l. The clinical picture consisted of an acrodermatitis enteropathica-like syndrome, with subsequent development of distinctive nail lesions, which consisted of white transverse bands in all finger- and toenails. Histopathological examination of several of these cutaneous lesions revealed distinctive changes, which we consider rather specific of zinc deficiency states. They consisted in parakeratosis, cleavage and detachment of the superficial layers of the epidermis, mainly intracellular and also extracellular edema of the epidermal cells, development of microvesicles at different epidermal levels, and severe vacuolar alteration of the dermoepidermal junction. These changes also affected the outer root sheath of the hair follicles.

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Dermopathic Changes in Hypozincemia

Cited by 10 publications

References 17 publications

Nutritional factors and hair loss

Nutritional factors and hair loss

Ernährung und Haarausfall

Acquired Zinc Deficiency Syndrome during Total Parenteral Alimentation

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