Dermatopathic lymphadenitis of the head and neck

Abstract

Dermatopathic lymphadenitis is a histopathologic diagnosis of patients with enlarged lymph nodes classically in the setting of a variety of inflammatory erthrodermas without known malignancy. While considered a benign histopathologic finding, differentiation of this disorder from mycosis fungoides or lymphoma can be difficult.

Mimicking Dermatopathic Lymphadenitis: An Entity of Lymphoma

“…1 The clinical presentation of DL is characterized by lymph node involvement instead of bony involvement and frequently includes a generalized skin disorder. 3 These characteristics of DL were not consistent with the patient's clinical manifestations, such as immobile enlarged lymph nodes, severe pain, and destruction of bone. A pathologist, orthopedist, and hematologist were consulted, and the search for another source of the malignant neoplasm was added to the diagnostic process.…”

“…3 Macroscopically, the enlarged lymph nodes are firm, moderately mobile, and rather painless. 4 Histologically, the lesion is characterized by melanin and fat-laden proliferated reticular elements (histiocytes and macrophages) residing in the cortical regions of the lymph nodes.…”

Hemophagocytic Lymphohistiocytosis Secondary to Dermatopathic Lymphadenitis

“…This disease could be easily confused with mycosis fungoides (Sézary syndrome). Hence, during diagnosis, care should be taken to discern between DL and malignant lymphoma [5].…”

Fine needle aspiration cytology of dermatopathic lymphadenitis in an asymptomatic female: A case report

“…[ 4 ] Even though a benign condition differentiating it from mycosis fungoides and malignant lymphoma can be difficult. [ 5 ]…”