Dermatomyositis‐like eruption with long‐term hydroxyurea

Elliott, R; Davies, Morton R.; Harmse, Dean

doi:10.1080/09546630500424805

Cited by 15 publications

(4 citation statements)

References 2 publications

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“…However, the cost implications, unavailability of necessary expertise, and the problems of finding suitable donor constitute a major setback to this approach in developing countries [5]. In clinical practice, blood transfusion, Hydroxyurea, Hydroxycarbamide, Clotrimazole, and erythropoietin are used in SCD management, but the side effects of these drugs such as iron overload and mutagenic and teratogenic assertions limit their clinical use [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds inTelfairia occidentalis

et al. 2016

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Background and Purpose. Traditional management of sickle cell disease (SCD) is ubiquitous in Africa. In south-eastern Nigeria, Telfairia occidentalis (T. occidentalis) is strongly recommended for consumption by SCD patients, owing to its presumed therapeutic effect. This study investigates the antisickling and membrane regenerative potentials of T. occidentalis in sickled erythrocytes. Experimental Approach. Sickled erythrocytes obtained from SCD patients were treated with sodium metabisulphite (2%) to induce further sickling. Heat and hypotonic-induced lyses of red blood cells' membranes were also carried out. The RBCs were treated with varying concentration (10.0, 1.0, and 0.1 mg mL−1 and 0.5, 1.0, 1.5, 2.0, and 2.5 mg mL−1, resp.) of T. occidentalis extracts as treatment regimen for in vitro antisickling and membrane stabilizing assays. Extract with peak activity was purified and reused in antisickling assay. Key Results. The antisickling activity of aqueous and methanolic extracts of leaves, seeds, and stem of Telfairia occidentalis at 10.0, 1.0, and 0.1 mg mL−1 revealed that the aqueous leaves extract (10 mg mL−1) exhibited the highest antisickling activity (64.03%) which was significantly (p < 0.05) higher than that of the stem (47.30%) and seeds (37.50%). Partially purified fractions recorded improved antisickling effect (peak activity of 70%). Characterization (using GC-MS) of the most active fraction revealed some bioactive compounds. In the membrane stabilizing assay, methanolic and aqueous stem extracts of T. occidentalis showed the highest effect of 71.85% and 61.29%, respectively. Conclusions and Implications. The results provide scientific evidence for ethnopharmacological use of T. occidentalis in the management of SCD.

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Section: Introductionmentioning

confidence: 99%

Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds inTelfairia occidentalis

et al. 2016

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“…Deux pourcent de la population en République Démocratique du Congo (RDC) sont touchés par cette maladie, soit plus d'un million d'habitants (Mpiana et al, 2007a). Près de 80% d'enfants atteints par cette anémie meurent avant leur cinquième anniversaire s'ils ne sont pas suivis médicalement (Stryer et al, 1997;Voet et Voet, 1998) Plusieurs modes de traitements ont été envisagés en vue de soulager les malades, entre autre le greffage de la moelle osseuse, la thérapie génétique, les transfusions sanguines répétées, la prise de l'hydroxyurée etc., Mais il s'avère que ces traitements sont non seulement inefficaces et très coûteux pour les populations pauvres d'Afrique, mais peuvent constituer également un risque d'infection au VIH/SIDA (Sofowora, 1998;Wajcman, 2003;Eliot et al, 2006).…”

Section: Introductionunclassified

Activité antidrépanocytaire et thermodégradation des anthocyanes extraits de Sterculia quinqueloba et Ficus capensis

Mpiana¹,

Balanganayi²,

Kanangila³

et al. 2009

International Journal of Biological and Chemical Sciences

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ASBSTRACT L'activité antifalcémiante de Ficus capensis et Sterculia quinqueloba, deux plantes utilisées en médicine traditionnelle contre la drépanocytose dans la ville de Lubumbashi (RD Congo), a été testée en utilisant le test d'Emmel. Les résultats obtenus ont montré une activité antifalcémiante importante in vitro pour les deux plantes. Cette activité serait due aux anthocyanes. Les concentrations minimales de normalisation des drépanocytes obtenus sont de 2,5 µg/ml et 3,0 µg/ml pour les anthocyanes de Ficus capensis et de Sterculia quinqueloba respectivement. Le fractionnement de ces anthocyanes par chromatographie sur couche mince utilisant les mélanges des solvants acétate d'éthyle-éthanol 96%-eau distillée-acide acétique 10 :5 :10 :1 pour Ficus capensis et benzène-méthanol-éthanol 96%-acide acétique 2 :4 :1 :1 a montré que ce sont les fractions ayant respectivement les rapports frontaux de 0,49 et 0,66 qui sont les plus actives. Ces anthocyanes ont montré une instabilité vis-à-vis de la chaleur. La cinétique de thermodégradation de la fraction la plus active des anthocyanes de Ficus capensis a donné les valeurs des constantes de vitesse expérimentales de 3,4 10-4 s-1 à 363 K et de 6,2 10-4 s-1 à 393 K.

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“…These treatments are inaccessible to African populations because they are very expensive. They can also pose a risk of transmitting diseases such as hepatitis and HIV/AIDS [7][8][9]. In Niger, the population has acquired several years of experience with the traditional treatment of illnesses using plants, as reported by [10] in an ethnobotanical survey of traditional health practitioners in the Tillabery and Niamey regions.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization and In Vitro Evaluation of the Anti-Sickle Cell Activity of Aqueous and Ethanolic Extracts of Two Medicinal Plants from Niger: Flueggea virosa (Roxb. ex Willd.) Royle and Kigelia africana (Lam.) Benth

Souleymane,

Djibo,

Seyni

et al. 2023

Plants

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Sickle cell anaemia is a hereditary blood disorder that attacks the red blood cells and deforms them, giving them a sickle shape. Sickle cell anaemia is a serious health problem in the West African country of Niger. Moreover, the cost associated with medical care is very high. The main objective of this study is to contribute to the valorisation of Flueggea virosa (Roxb. ex Willd.) Royle (aerial part), Kigelia africana (lam), and Benth (leaves) from Niger were used to treat sickle cell disease using aqueous and ethanolic extracts of phytochemical compounds. To achieve this objective, the evaluation of anti-sickle cell activity was carried out in vitro using the Emmel technique through the normalisation rate. The analyses showed that the aqueous and ethanolic extracts contained various classes of bioactive substances known for their valuable biological activities. The chemical composition rich in bioactive compounds led to very good results in biological assays. Thus, from a dose of 0.05 mg/mL, the ethanolic extracts of the two plants normalised up to 75% of the sickle cells. As the rate of normalisation was shown to be dose-dependent, at a dose of 10 mg/mL, the ethanolic extracts showed the best rates of sickle cell normalisation, with 95% for F. virosa and 93% for K. africana. Phytochemical screening was used to correlate the secondary metabolite and anti-sickle cell activities of the extracts from the two plants. These results may justify the use of these two species in traditional medicine for the treatment of sickle cell disease in Niger. The inclusion of these plants in phytomedicines could provide significant relief to people suffering from sickle cell disease.

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Dermatomyositis‐like eruption with long‐term hydroxyurea

Cited by 15 publications

References 2 publications

Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds inTelfairia occidentalis

Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds inTelfairia occidentalis

Activité antidrépanocytaire et thermodégradation des anthocyanes extraits de Sterculia quinqueloba et Ficus capensis

Phytochemical Characterization and In Vitro Evaluation of the Anti-Sickle Cell Activity of Aqueous and Ethanolic Extracts of Two Medicinal Plants from Niger: Flueggea virosa (Roxb. ex Willd.) Royle and Kigelia africana (Lam.) Benth

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