Dermatomyositis and mucinosis

Pozo, Jesús del; Almagro, Manuel; Martínez, Walter; Yebra‐Pimentel, María Teresa; García-Silva, J.; Peña-Penabad, Carmen; Fonseca, Eduardo

doi:10.1046/j.1365-4362.2001.01060.x

Cited by 37 publications

(22 citation statements)

References 21 publications

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“…12 In addition, patients with dermatomyositis may develop atypical clinical lesions secondary to cutaneous mucin deposition. 13 To date, markers of autoimmune disease including antinuclear antibody, rheumatoid factor, and complement levels in several of the reported cases of SHJCM have not revealed evidence of autoimmunity. 3,4,[6][7][8] Taken together, however, we believe patients suggested to have SHJCM should at minimum be evaluated with creatine kinase and aldolase testing for the presence of elevated muscle enzymes.…”

Section: Discussionmentioning

confidence: 98%

Self-healing juvenile cutaneous mucinosis

Cowen

Scott

Mercurio

2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 98%

Self-healing juvenile cutaneous mucinosis

Cowen

Scott

Mercurio

2004

Journal of the American Academy of Dermatology

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“…Pandya et al linked the increased level of serum autoantibody titres with an increase in mucin lesions in patients with SLE [11, 15]. Interleukin-1 and interleukin-6 have also been shown to be elevated in patients with increased dermal mucin production in SLE and DM; however this is nonspecific as interleukins may be raised without evidence of mucinosis [2]. …”

Section: Discussionmentioning

confidence: 99%

“…Clinically evident forms of mucinosis have been described in hypothyroidism, thyrotoxicosis, scleromyxedema associated with monoclonal gammopathies, scleredema related to diabetes, and lichen myxedematosus. Cases of secondary cutaneous mucinosis have been described in systemic lupus erythematosus, systemic sclerosis, and dermatomyositis, albeit infrequently [2–8]. We present a case of dermatomyositis with evidence of diffuse cutaneous mucinosis in a patient recently treated for nonsmall cell lung cancer (NSCLC) without evidence of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Diffuse Cutaneous Mucinosis in Dermatomyositis: A Case Report and Review of the Literature

Perel-Winkler

Derk

2014

Case Reports in Dermatological Medicine

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“…(7,10,11) Skin biopsy can show chronic perivascular and peri-adnexal inflammation, and mucin deposits are common findings. (12) In addition, CD4+ cells can be found in the dermis. (11) Muscle involvement is suspected when proximal and progressive symmetric weakness, manifesting as inability to climb stairs or raise the arms, is reported.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma pulmonar, dermatomiosite e síndrome miastênica de Lambert-Eaton: uma rara associação

et al. 2008

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The incidence of lung neoplasms is increasing in Brazil and in the world, probably as a result of the increase in smoking. Due to the greater number of cases, atypical presentations appear. We report the case of a 66-year-old hypertensive male smoker who presented progressive proximal muscular weakness and, in two months, evolved to dysphagia, dysphonia, and V-shaped skin lesions on the chest. A chest X-ray showed a spiculated pulmonary nodule in the right upper lobe. The biochemical analysis revealed elevated creatine kinase levels. After complementary tests and biopsies, the patient underwent right upper lobectomy. Histopathology showed a moderately differentiated adenocarcinoma. The overall analysis of the case and a review of the literature allow us to suggest that the clinical profile of the patient was a result of an overlap of two paraneoplastic syndromes (dermatomyositis and Lambert-Eaton myasthenic syndrome) secondary to lung adenocarcinoma.Keywords: Lung neoplasms; Paraneoplastic syndromes; Dermatomyositis; Lambert-Eaton myasthenic syndrome; Adenocarcinoma. ResumoA incidência das neoplasias pulmonares vem aumentando no Brasil e no mundo, provavelmente como resultado do aumento do tabagismo. Com o maior número de casos, surgem as apresentações atípicas. Relatamos o caso de um paciente do sexo masculino, 66 anos, tabagista e hipertenso, que apresentava quadro de fraqueza muscular proximal progressiva e, em dois meses, evoluiu com disfagia para alimentos sólidos, disfonia e lesões cutâneas em forma de "V" no tórax. O radiograma de tórax mostrou um nódulo pulmonar espiculado no lobo superior direito. A análise bioquímica revelou aumento da creatinoquinase. Após exames complementares e biópsias, o paciente foi submetido à lobectomia superior direita. A histopatologia evidenciou um adenocarcinoma moderadamente diferenciado. A análise global do caso e a revisão de literatura permitem sugerir que o quadro clínico do paciente era resultante da sobreposição de duas síndromes paraneoplásicas, a saber, a dermatomiosite e a síndrome miastênica de Lambert-Eaton, secundárias a um adenocarcinoma pulmonar.

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Dermatomyositis and mucinosis

Abstract: Mucin deposition in patients with dermatomyositis may have an unusual clinical presentation, and it should be considered in the differential diagnosis of atypical cutaneous lesions in these patients.

Cited by 37 publications

References 21 publications

Self-healing juvenile cutaneous mucinosis

Self-healing juvenile cutaneous mucinosis

Diffuse Cutaneous Mucinosis in Dermatomyositis: A Case Report and Review of the Literature

Adenocarcinoma pulmonar, dermatomiosite e síndrome miastênica de Lambert-Eaton: uma rara associação

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