Diffuse Cutaneous Mucinosis in Dermatomyositis: A Case Report and Review of the Literature

Perel-Winkler, Alexandra; Derk, Chris T.

doi:10.1155/2014/938414

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…We found that 95% of involved dermatomyositis skin biopsy specimens had at least one of basal vacuolization, mucin, or perivascular inflammation, while 91% had at least one of basal vacuolization or dyskeratotic keratinocytes. These results are similar to literature reports of mucin, basal vacuolization, and perivascular inflammation, including findings from a large study that found vacuolization within 85% of biopsy specimens, mucin within 98% and perivascular inflammation within 94% . Similar to others, we did not find significant overlap between basal vacuolization and mucin (Figure ) .…”

Section: Discussionsupporting

confidence: 91%

Clinical factors associated with cutaneous histopathologic findings in dermatomyositis

et al. 2019

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Background: Common histopathologic findings in cutaneous dermatomyositis include vacuolar interface with dyskeratosis, mucin, and perivascular inflammation. Data examining the relationships between these and other histologic abnormalities, or their dependence on biopsy site, and medications are limited. Methods: Using 228 dermatomyositis skin biopsies and statistical analyses including Chi-squared analyses, calculations of relative risk, and adjusted generalized estimating equation regressions, we investigated relationships between 14 histopathologic findings and the impact of clinical factors on these findings. Results: In biopsies taken from sites of visible rash, interface dermatitis was seen in 91%, and 95% had at least one of perivascular inflammation, mucin, or basal vacuolization. Vascular abnormalities were not closely associated with epidermal or inflammatory findings. Concomitant prednisone significantly decreased the odds of basal vacuolization (odds ratio [OR] = 0.34, 95% confidence interval [CI]: 0.12-0.98, P-value = 0.05), perivascular inflammation (OR = 0.19, 95% CI: 0.07-0.53, P-value = 0.002), and vessel damage (OR = 0.81, 95% CI: 0.68-0.96, P-value = 0.02). Conclusion: Vasculopathy and classic findings of interface dermatitis may be driven by unique pathways in dermatomyositis. Corticosteroid use may impact skin biopsy findings. There is a need for clinicopathologic correlation when diagnosing dermatomyositis. K E Y W O R D S dermatomyositis, dermatopathology, interface dermatitis, vasculopathy

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Section: Discussionsupporting

confidence: 91%

Clinical factors associated with cutaneous histopathologic findings in dermatomyositis

et al. 2019

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“…However, rarely a secondary form of mucin deposition in a CTD can produce macroscopic deposits of mucin leading to clinical lesions. [15][16][17][18] These clinical mucino-ses are still secondary and must be differentiated from a primary mucinosis in a CTD.…”

Section: Discussionmentioning

confidence: 99%

Review of Primary Cutaneous Mucinoses in Nonlupus Connective Tissue Diseases

2017

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Lichen myxedematosus is an idiopathic, cutaneous mucinosis with 2 clinicopathologic subsets. There is the generalised papular and sclerodermoid form, more properly termed scleromyxedema, and the localised papular form. We report the first case, to our knowledge, of lichen myxedematosus in association with rheumatoid arthritis as well as a case in association with dermatomyositis. An up-to-date literature review on cutaneous mucinoses and connective tissue diseases, excluding the common association of primary and secondary mucinoses with systemic lupus erythematosus, was also performed.

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“…No active cancer was found on full body PET-CT; muscle enzymes were normal; however, MRI showed hyperenhancement of quadriceps muscles bilaterally. The patient did not respond to steroids or methotrexate and required IVIG for symptomatic resolution [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Docetaxel Induced Myositis and Review of the Literature

Perel-Winkler

Belokovskaya

Amigues

et al. 2015

Case Reports in Rheumatology

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In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, and fluid retention. With further use of these agents, studies in the late 1980s and early 1990s began to report peripheral neuropathy and proximal muscle weakness as common complaints, the later with unexplained pathophysiology. We report a 65-year-old Hispanic woman with estrogen receptor (ER) and progesterone receptor (PR) positive invasive ductal breast carcinoma who presented with right thigh pain and swelling eight days after her third infusion of docetaxel (a taxane chemotherapeutic) and cyclophosphamide. Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs. A workup to rule out other causes of myositis was negative. Docetaxel was not reintroduced and the patient improved with corticosteroids. Since 2005 this is, to our knowledge, the fifth reported case of docetaxel related inflammatory myositis. Taxanes have been noted to cause disabling but transient arthralgias and myalgias; it is important to consider the possibility of inflammatory myopathy as a possible complication in patients undergoing treatment with these agents.

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Diffuse Cutaneous Mucinosis in Dermatomyositis: A Case Report and Review of the Literature

Cited by 5 publications

References 24 publications

Clinical factors associated with cutaneous histopathologic findings in dermatomyositis

Clinical factors associated with cutaneous histopathologic findings in dermatomyositis

Review of Primary Cutaneous Mucinoses in Nonlupus Connective Tissue Diseases

A Case of Docetaxel Induced Myositis and Review of the Literature

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