Dermatomyositis

Callen, Jeffrey P.

doi:10.1016/0011-5029(87)90022-8

Cited by 16 publications

(2 citation statements)

References 194 publications

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“…This opens the possibility that juvenile DMS may be a syndrome with many variations. Callen (17) reported that skin lesions from DMS can be difficult to treat and may stay the same or even worsen even when symptoms otherwise abate through treatment. The fact that intractable cutaneous manifestations were seen in our cases ofjuvenile DMS as well makes us wonder whether some factor unique to juvenile DMS could be involved which would make it an entity separate from adult DMS.…”

Section: Discussionmentioning

confidence: 99%

Juvenile Dermatomyositis: A Statistical Study of 114 Patients with Dermatomyositis

Hiketa

Matsumoto

Ohashi

et al. 1992

The Journal of Dermatology

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We conducted a statistical review of 114 cases of dermatomyositis (DMS) treated primarily at the Department of Dermatology at Nagoya University Hospital over 27 years from 1965 to 1991 in order to determine the primary characteristics of juvenile DMS with the following results. 1) Juvenile DMS was found slightly more often in males than females; the male-to-female ratio was 1.4:1. Therefore, unlike adult DMS with its preponderance of females, there was no clear gender predominance. 2) Muscular manifestations tended to follow the appearance of cutaneous manifestations, but the frequency of minor muscular manifestations was high over the entire course of the disease. 3) Laboratory findings showed increases in serum aldolase and serum creatinine kinase with significant frequency when compared with adult patients (p < 0.01 and p < 0.05, respectively). Elevated serum aldolase most often occurred prior to or at the time of the appearance of muscular manifestations, suggesting its usefulness in early diagnosis. The positive rates for the antinuclear antibody on HEp-2 cells and anti-DNA antibody were significantly lower in children than in adults (p < 0.001 and p < 0.05, respectively). 4) There were no cases of juvenile DMS complicated by malignant tumors, interstitial pneumonia, or pulmonary fibrosis. There were also no deaths, and the rate of "remission or improvement" was significantly higher than in adult DMS cases (p < 0.05). Adult cases which remained the same or worsened usually presented with intractable muscular manifestations. In children, however, the cutaneous manifestations were more difficult to treat.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Juvenile Dermatomyositis: A Statistical Study of 114 Patients with Dermatomyositis

Hiketa

Matsumoto

Ohashi

et al. 1992

The Journal of Dermatology

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“…2 Polymyositis is differentiated from dermatomyositis by the absence of the characteristic cutaneous lesions. 1 Stahl et al 3 reported the presence of hyperkeratosis of the fleshy pad and the lateral aspect of the fingers to be a marker for idiopathic inflammatory myositis. We describe a woman with primary polymyositis associated with hyperkeratosis of the fingers of both hands.…”

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A Cutaneous Lesion Associated With Primary Polymyositis

Indart¹

1993

Arch Dermatol

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Polymyositis is a nonsuppurating inflammatory disease of the striated muscle characterized clinically by the presence of proximal muscular weakness that is sometimes associated with pain. 1 This disease falls within a broader category known as idiopathic inflammatory myopathy, which includes the forms of myositis that are secondary to connective tissue disease and neoplasms and myositis with inclusion bodies. 2 Polymyositis is differentiated from dermatomyositis by the absence of the characteristic cutaneous lesions. 1 Stahl et al 3 reported the presence of hyperkeratosis of the fleshy pad and the lateral aspect of the fingers to be a marker for idiopathic inflammatory myositis. We describe a woman with primary polymyositis associated with hyperkeratosis of the fingers of both hands. REPORT OF A CASEA 55-year-old housewife presented in August 1991 with arthromyalgia, predominantly in the-upper limbs, affecting the shoulders, wrists, and metacarpophalangeal and proximal interphalangeal joints of both hands. She also complained of having a sensation of loss of strength. The patient also reported the parallel development of fissures and thickening of the distal portion of the fingers of both hands.After treatment with nonsteroidal antiinflammatory drugs, the polyarthralgia improved, but the fingertip lesions remained unchanged. The patient later noted generalized muscular weakness with stiffness, pain, and heaviness of the lower extremities that limited her ability to perform household tasks, climb stairs, and sit in a chair. During this second phase, edema of the feet and legs appeared. There were no other cutaneous

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Connection of atopic disease in Japanese patients with juvenile dermatomyositis based on serum IgE levels

et al. 1993

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Serum IgE levels of 22 patients with juvenile dermatomyositis (JDMS), 44 normal children, and 43 patients with adult dermatomyositis were compared. The geometric mean of serum IgE levels was significantly higher in the juvenile patients when compared with normal children (p < 0.01) and adult patients (p < 0.01). Of the 22 patients with JDMS, 11 (50%) had elevated serum IgE levels accompanied by atopic disease. Dermatomyositis was accompanied by atopic dermatitis (AD) in 9 (41%) of these 22 patients, a high prevalence when compared with reports among the general population. Following the appearance of muscular symptoms in JDMS patients with AD, the ratio of OKT4 to OKT8 cells rose due to a reduction in the percentage of OKT8-positive cells, along with further elevations in serum IgE levels and intractable cutaneous manifestations of dermatomyositis. All this may be a result of an interaction between the immuno-mechanism of this disease and that of AD. We suspect that, in general, children with impaired cell-mediated immunity, presenting with such symptoms as AD, may have a higher tendency for developing JDMS.

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Dermatomyositis

Cited by 16 publications

References 194 publications

Juvenile Dermatomyositis: A Statistical Study of 114 Patients with Dermatomyositis

Juvenile Dermatomyositis: A Statistical Study of 114 Patients with Dermatomyositis

A Cutaneous Lesion Associated With Primary Polymyositis

Connection of atopic disease in Japanese patients with juvenile dermatomyositis based on serum IgE levels

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