Connection of atopic disease in Japanese patients with juvenile dermatomyositis based on serum IgE levels

Ishida, Tadao; Ohashi, Masaru; Matsumoto, Yoshihiro; Morikawa, J; Sasaki, Ryuichiro

doi:10.1007/bf02231557

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…In accordance with Ishida et al [17] who stated that JDM patients have significantly higher levels of total IgE, we observed such regularity in 4 patients.…”

supporting

confidence: 92%

A New Outlook on Clinical Course of Juvenile Dermatomyositis - Experience of a Single Center

Orczyk¹,

Świdrowska²,

Stańczyk³

et al. 2015

Int J Pediatr Res

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mild muscle symptoms that are easy to treat and never relapse, to a therapy-resistant chronic condition [5].JDM diagnosis is based on the Bohan & Peter criteria [6] originally developed for adult patients: symmetric proximal muscle weakness, biopsy-proven myositis, elevated serum muscle enzyme levels, electromyographic changes of myositis. JDM may be also misdiagnosed as polymyositis in patients presenting with isolated muscle symptoms on first admission [7].The pathogenesis of JDM is not completely understandable yet. Viral infection or immune dysfunction may trigger disease in patients with genetic predispositions [1]. Accordingly, the identification of novel autoantibodies in JDM (such as anti-p155/140, anti-p140) may have clinical implications, as they are associated with specific clinical features, treatment response and prognosis [8].Dermatomyositis is also considered as one of paraneoplastic syndromes in adults. It is believed to occur in 7-15% of all cancer patients [9]. The association of dermatomyositis and cancer is more likely to happen in elderly people [10], but it may also coincide with leukemia and lymphoma in pediatric patients [11].As JDM differs from the course of disease in adults, diagnostic criteria require a new approach. They do not consider radiologic methods such as MRI, which is recently becoming the preferred non-invasive test indicating muscle inflammation, instead of muscle biopsy and electromyography (EMG) included in the criteria [3].In order to adjust criteria to pediatric patients, differences in clinical course of dermatomyositis between adults and children need to be reported. Therefore we present series of 5 cases. Materials and MethodsThe retrospective study included the medical charts of 8 patients ≤18 years of age who were treated due to JDM suspicion at the

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“…In accordance with Ishida et al [17] who stated that JDM patients have significantly higher levels of total IgE, we observed such regularity in 4 patients.…”

supporting

confidence: 92%

A New Outlook on Clinical Course of Juvenile Dermatomyositis - Experience of a Single Center

Orczyk¹,

Świdrowska²,

Stańczyk³

et al. 2015

Int J Pediatr Res

View full text Add to dashboard Cite

show abstract

“…A dermatomyositis-like illness has also been observed in children with congenital hypo-or agammaglobulinemia and usually accompanies disseminated or central nervous system echovirus infections (8,159). Elevated serum IgE levels have been observed in some patients with JDM, but not in adult patients with DM, particularly in those with intractable skin disease, atopy, or calcinosis (52,87,105).…”

Section: Immunologic Abnormalities In the Iimmentioning

confidence: 99%

Laboratory evaluation of the inflammatory myopathies

Rider

Miller

1995

Clin Diagn Lab Immunol

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The laboratory plays an important role in the diagnosis, evaluation, and classification of the heterogeneous group of diseases known as the IIM, which are characterized by chronic muscle inflammation. Serial measurements of the levels of muscle-derived enzymes in serum are the traditional laboratory studies used to follow the clinical course of patients with IIM, although other laboratory tests can also be useful in assessing myositis disease activity. Several markers of immune system activation, including cytokines and lymphocyte markers, show promise as possibly more sensitive measures of myositis disease activity. Discovery of a unique group of MSAs over the past decade has provided an immunologic basis for defining relatively homogeneous subsets of patients who share similar clinical features, disease courses, and responses to therapy. Future investigations of novel immunologic activation markers, as well as the cloning and expression of target autoantigens of the MSAs, should allow better diagnostic assays, enhanced prognosis, and a better understanding of the pathogenesis of these disorders.

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“…S. aureus infection with elevated serum IgE is rarely observed in juvenile DM, and this can be partially explained by the previous two reports. First, atopic dermatitis, which is frequently accompanied by S. aureus , has a higher tendency for developing juvenile DM 3 ) . Second, the development of calcinosis and granulocyte chemotactic defect in juvenile DM is associated with staphylococcal infections 4 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Intercurrent infections with elevated serum IgE level during the course of the disease give rise to problems in patients with juvenile DM. Atopic dermatitis, or development of calcinosis, may contribute to this problem 3 , 4 ) . HIE also has the characteristic findings of recurrent infections of the skin and sinopulmonary tract and high serum IgE level.…”

Section: Introductionmentioning

confidence: 99%

Hyperimmunoglobulin E - Recurrent Infection Syndrome In A Patient With Juvenile Dermatomyositis

Min

Cho

Kim

et al. 1999

Korean J Intern Med

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A 13-year-old girl presented with multiple skin abscesses. She was diagnosed as having juvenile dermatomyositis (DM) at the age of 7 years. She had suffered from recurrent skin infections, atypical pruritic dermatitis and pneumonia since the age of 8 years. Bacteriologic and fungal cultures for skin abscesses and oral mucosa were positive S. aureus and C. albicans, respectively. Chemotactic defect in peripheral blood neutrophils was observed. The level of serum IgE was markedly elevated, and anti-S.aureus specific IgE was found. A diagnosis of hyperimmunoglobulin E-recurrent infection syndrome (HIE) was made and she was successfully treated with surgical drainage and antibiotics. To our knowledge, this is the first case report of HIE in a patient with juvenile dermatomyositis.

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Connection of atopic disease in Japanese patients with juvenile dermatomyositis based on serum IgE levels

Cited by 6 publications

References 28 publications

A New Outlook on Clinical Course of Juvenile Dermatomyositis - Experience of a Single Center

A New Outlook on Clinical Course of Juvenile Dermatomyositis - Experience of a Single Center

Laboratory evaluation of the inflammatory myopathies

Hyperimmunoglobulin E - Recurrent Infection Syndrome In A Patient With Juvenile Dermatomyositis

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