Dermatomyositis

O’leary, Paul A.

doi:10.1001/archderm.1940.01490120003001

Cited by 134 publications

(23 citation statements)

References 9 publications

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“…Another evidence of disturbed arterial function is the occurrence of Raynaud's phenomenon in as many as 25 per cent of cases. 23 Admittedly there is much that is speculative about the significance of the findings in these two cases and similar ones noted by others. Although vascular lesions have not been reported in a majority of contemporary autopsied cases of dermatomyositis, the possibility that abnormalities of function of the vascular beds of the affected organs underlie the development of the disorder, as well as a possible potentiating effect of steroid therapy on their development warrant further consideration.…”

Section: Discussionsupporting

confidence: 56%

Vascular lesions in dermatomyositis

Boylan

Sokoloff

1960

Arthritis & Rheumatism

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Extensive vascular lesions were found Extense lesiones vascular esseva trovate at necropsy in two childhood cases of a1 necropsia in duo casos de dermatodermatomyositis. Attention is drawn to myositis in juveniles. Attention es appelthe role of blood vessels in the patho-late a1 rolo del vasos sanguin in le genesis of this disease and to the possi-pathogenese de iste morbo e a1 possibile ble effect of steroid therapy on their effect0 de therapia a steroides super le development.disveloppamento del lesiones. HE ANATOMIC FINDINGS generally described in dermatomyositisT are variable and nonspecific. The histologic appearance of striated muscle is similar to that seen in polymyositis, systemic l i p s erythematosus, generalized scleroderma, neoplastic diseases, and others. One of the features that has distinguished dermatomyositis from other so-called collagen diseases is the reputed absence or paucity or vascular lesions in this disorder. Actually, examination of the literature on dermatomyositis discloses little systematic anatomic information on the state of the blood vessels. Scattered instances of vascular damage were reviewed by Schuermann in 1938.lIn only one recent report; has it been suggested that vascular lesions occur with some frequency, if not regularity. Although no detailed account of the pathologic findings was offered in that paper, the brief description corresponds to what we have observed recently in two cases at necropsy. These cases are being reported to draw attention to vascular changes in dermatomyositis. CASE HISTORIES Case 1A six-year old boy died after an illness of 1% years' duration. There was an insidious loss of appetite and malaise initially followed by a slowly progressive scaling, erythematous eruption of the extremities and face. Prominent swelling developed about the lips and eyes with heliotrope discoloration of the eyelid?. Shortly after this, muscle weakness, pain and tenderness appeared, most pronounced in the back and shoulder girdle. The patient was first treated with corticotropin, and later with prednisolone, hydrocortisone and cortisone.During the steroid therapy fluctuating hypertension (up to 160/130 mm. Hg.) appeared.

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Section: Discussionsupporting

confidence: 56%

Vascular lesions in dermatomyositis

Boylan

Sokoloff

1960

Arthritis & Rheumatism

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“…Six years earlier she had migratory poly arthritis, and she later developed a well-documented mitral stenosis (223). Two other instances of valvular cardiac disease were reported in another study of 40 patients with dermatomyositis, but no details were given (224). Further detailed studies of such patients and their families might be en lightening.…”

Section: Interrelationships With Other Mesenchymal Diseasesmentioning

confidence: 96%

“…Rheumatic fever.-There have been several reports of rheumatic fever and dermatomyositis occurring in the same patient (223,224).…”

Section: Interrelationships With Other Mesenchymal Diseasesmentioning

confidence: 98%

Interrelationships of the Mesenchymal Diseases with Consideration of Possible Genetic Mechanisms

Peterson¹,

Good²

1963

Annu. Rev. Med.

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“…It is this distribution of muscular wasting which has led to confusion with muscular dystrophy, so that muscle biopsy is essential for the diagnosis of most cases of subacute and chronic polymyositis. As the disease involves necrosis of muscle, creatinuria has been found to be a constant feature of it (O'Leary and Waisman, 1940;Jager and Grossman, 1944;Cumings, 1953), and persists as long as the disease remains active. With regard to the prognosis of polymyositis and dermatomyositis, it is now well recognized that up to 50% of the florid cases terminate fatally, usually from pharyngeal or respiratory paralysis or from associated bronchopneumonia.…”

Section: Discussonmentioning

confidence: 99%

Polymyositis

Bg¹,

Am²,

Jh³

1960

BMJ

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Dermatomyositis

Cited by 134 publications

References 9 publications

Vascular lesions in dermatomyositis

Vascular lesions in dermatomyositis

Interrelationships of the Mesenchymal Diseases with Consideration of Possible Genetic Mechanisms

Polymyositis

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