Interrelationships of the Mesenchymal Diseases with Consideration of Possible Genetic Mechanisms

Procainamide-induced systemic lupus erythematosus.

“…Why some but not all should be affected is not clear, but genetic factors may be implicated. In the case of spontaneous lupus erythematosus, a familial incidence has been reported (Peterson and Good, 1963). It is recognized that there is frequently a well-substantiated family history of rheumatic disease in these patients (Holley, 1964).…”

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

“…The terms "connective tissue disease" and "collagen disease" were used interchangeably to describe that group of disorders characterized by multi-system clinical manifestations together with diffuse vascular lesions, fibrinoid deposits, degenerative connective tissue changes and frequently associated with inflammatory cellular reactions (980,1223,1293); other terms such as "collagenosis" (664) and mesenchymal discase (980,1359) were less frequently used.…”

“…] The term "connective tissue disease" was generally considered to include rheumatoid arthritis, systemic lupus erythematosus (SLE ), scleroderma, pcriarteritis nodosa, dermatomyositis and, in some instances, acute rheumatic fever and thrombotic thrombocytopenic purpura (980,1223,1293); it was recognized that the term as used did not include congenital disorders of connective tissue nor a large number of other disorders in which the connective tissue involvement was of a diff ercnt nature ( 1223). The clinical, pathological and immunological similarities among the various connective disorders were discussed (93, 664,686,980,1149,1223,1293) and it was again noted that individual patients may have combined features of two or more of these disorders (93, 664,743,1149). A family was reported in which rheumatoid arthritis, SIX, thymoma, rheumatic fever, regional enteritis, thrombocytopenic purpura and immunoglobulin deficiency were noted ( 1359) and the possible interrelationship between these disorders was discussed (980,1359).…”

“…The clinical, pathological and immunological similarities among the various connective disorders were discussed (93, 664,686,980,1149,1223,1293) and it was again noted that individual patients may have combined features of two or more of these disorders (93, 664,743,1149). A family was reported in which rheumatoid arthritis, SIX, thymoma, rheumatic fever, regional enteritis, thrombocytopenic purpura and immunoglobulin deficiency were noted ( 1359) and the possible interrelationship between these disorders was discussed (980,1359). Current concepts of the possible pathogenesis of the connective tissue diseases were reviewed (1293).…”

“…There was speculation concerning mechanisms by which an individual's tissue constituents may be rendered autoantigenic (152,172,178,192,255,779,930,976,1040,1103,1152,1250,1293,1293,1299). The possible role of the thymus in autoimmune phenomena (177,457,547,580) and in connective tissue disorders (14,419,456,457,508,599,673,680,707,776,777,780,980,1293) was considered.…”