Dermatologie care behind bars

Brauner, G; Goodheart, Herbert P.

doi:10.1016/s0190-9622(88)70107-3

Cited by 22 publications

(21 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[75][76][77] Some did not find a significant correlation of hair loss onset with stressful life events, 78-80 while others confirm stressful events in AA patients before the onset of disease. 30,79,81 In contrast, several studies have shown that individuals with AA are more likely to exhibit aberrant psychosocial traits, such as increased anxiety, depression, and aggression.…”

Section: Environmental Impact On Alopecia Areatamentioning

confidence: 99%

Alopecia areata update

Alkhalifah

Alsantali

Wang

et al. 2010

Journal of the American Academy of Dermatology

424

223

View full text Add to dashboard Cite

Section: Environmental Impact On Alopecia Areatamentioning

confidence: 99%

Alopecia areata update

Alkhalifah

Alsantali

Wang

et al. 2010

Journal of the American Academy of Dermatology

424

223

View full text Add to dashboard Cite

“…Anecdotally, stressful life events have been suggested as a trigger for onset of AA (Barber, 1921; Brauner and Goodheart, 1988). However, the results of controlled clinical studies on the association of stress with AA have been inconclusive (Greenberg, 1955; Perini et al, 1984; Gupta et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Development of Alopecia Areata Is Associated with Higher Central and Peripheral Hypothalamic–Pituitary–Adrenal Tone in the Skin Graft Induced C3H/HeJ Mouse Model

Zhang

et al. 2009

Journal of Investigative Dermatology

View full text Add to dashboard Cite

The relationship of the stress response to the pathogenesis of alopecia areata (AA) was investigated by subjecting normal and skin graft-induced, AA-affected C3H/HeJ mice to light ether anesthesia or restraint stress. Plasma corticosterone (CORT), adrenocorticotropic hormone (ACTH), and estradiol (E2) levels were determined by RIA, whereas gene expression in brains, lymphoid organs, and skin was measured by quantitative RT-PCR for corticotropin-releasing hormone (Crh), arginine vasopressin (Avp), proopiomelanocortin (Pomc), glucocorticoid receptor (Nr3c1), mineralo corticoid receptor (Nr3c2), corticotropin-releasing hormone receptor types 1 and 2 (Crhr1, Crhr2), interleukin-12 (Il12), tumor necrosis factor-α (Tnfα), and estrogen receptors type-1 (Esr1) and type-2 (Esr2). AA mice had a marked increase in hypothalamic–pituitary–adrenal (HPA) tone and activity centrally, and peripherally in the skin and lymph nodes. There was also altered interaction between the adrenal and gonadal axes compared with that in normal mice. Stress further exacerbated changes in AA mouse HPA activity both centrally and peripherally. AA mice had significantly blunted CORT and ACTH responses to acute ether stress (physiological stressor) and a deficit in habituation to repeated restraint stress (psychological stressor). The positive correlation of HPA hormone levels with skin Th1 cytokines suggests that altered HPA activity may occur as a consequence of the immune response associated with AA.

show abstract

“…Psychological stress has been recognized as a trigger for AA [38,[86][87][88][89][90][91]. The association of stress and LPP is not as clear, although the oral variant of lichen planus has been linked with stress [92].…”

Section: Could Stress Play a Role?mentioning

confidence: 99%

Immune Privilege Collapse and Alopecia Development: Is Stress a Factor

Azzawi¹,

Penzi²,

Senna³

2017

Skin Appendage Disord

View full text Add to dashboard Cite

Hair is a defining mammalian feature that serves as a hallmark of human communication. Given the critical significance of hair in social, religious, and political contexts, it is important to understand factors that play a role in hair loss disorders. The hair follicle is an immune privileged site, and mounting evidence suggests that the collapse of immune privilege contributes to the pathogenesis of autoimmune hair loss disorders, including alopecia areata and lichen planopilaris. This review comprehensively appraises the current literature to shed light on mechanisms for immune privilege collapse, and examines the role of neurogenic stress in triggering this process.

show abstract

Dermatologie care behind bars

Cited by 22 publications

References 5 publications

Alopecia areata update

Alopecia areata update

Development of Alopecia Areata Is Associated with Higher Central and Peripheral Hypothalamic–Pituitary–Adrenal Tone in the Skin Graft Induced C3H/HeJ Mouse Model

Immune Privilege Collapse and Alopecia Development: Is Stress a Factor

Contact Info

Product

Resources

About