Alopecia areata update

Alkhalifah, Abdullah; Alsantali, Adel; Wang, Eddy; McElwee, Kevin J.; Shapiro, Jerry

doi:10.1016/j.jaad.2009.10.032

Cited by 410 publications

(224 citation statements)

References 97 publications

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“…Psikiyatrik tanı alma ise %42. 2 Psikiyatrik tanı alan AA hastalarında psikiyatrik tanı almayanlara göre ÇDÖ anlamlı düzeyde daha yüksektir (n=13/12, z=-2.917 p=0.004). Yine psikiyatrik tanı alan grupta almayanlara göre ADÖ genel işlevler puanları da anlamlı düzeyde yüksek saptanmıştır (n=14/19, z=-2.011 p=0.044).…”

Section: Bulgularunclassified

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Family functioning, psychopathology and quality of life in children and adolescents with alopecia areata

Kutlu¹,

Kundak²

2016

BUCH

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ÖZAmaç: Alopesi areata (AA) tanılı çocuk ve ergenlerde aile işlevselliği, psikopatoloji ve yaşam kalitesini belirlemek sosyodemografik ve hastalık ile ilgili değişkenlerle ilişkisini araştırmaktır. Yöntem: İki-18 yaş arasındaki 45 hasta retrospektif olarak incelendi. Aile Değerlendirme Ölçeği (ADÖ), Çocuklar ve Gençler İçin Yaşam Kalitesi Ölçeği (ÇYKÖ), Çocuklar için Depresyon Ölçeği (ÇDÖ) ile Sosyodemografik veri formu kullanılmıştır. İstatistiksel analizde SPSS 18.0 programı kullanılmıştır. Bulgular: Çalışma grubunun yaş ortalaması 9.22±3.79 yıldır ve %55.6'sı kadındır. Tüm olgu grubunda ADÖ gereken ilgiyi gösterme ve davranış kontrolü alt ölçeklerinde sorun olduğu belirlenmiştir (>2). Olguların %42.2'si en az bir psikiyatrik tanı almıştır. Psikiyatrik komorbidite varlığı; depresyon, ADÖ genel işlevler, Ebeveyn yaşam kalitesi psikososyal sağlık, çocuk yaşam kalitesinde de tüm alanlarda bozulmaya neden olmuştur. Olguların %51.1'inde psikososyal tetikleyici olay tespit edilmiştir. Ama tetikleyici olay saptanmayan olgularda ÇDÖ ve ÇYKÖ tüm alanlarda anlamlı düzeyde bozulmuştur (p<0.05). Lezyon yaygınlığı yalnızca, atak sayısı ve hastalık süresi ile pozitif yönde ilişkili bulunmuştur. Sonuç: AA hastalarında aile işlevselliği gereken ilgiyi gösterme ve davranış kontrolü alanlarında bozuktur. Psikososyal tetikleyici olaylar AA'da sık olmasına rağmen psikopatoloji, yaşam kalitesi ve aile işlevselliği ile ilişkili olmayabilir. Psikiyatrik komorbidite yaşam kalitesini en fazla bozan faktör olmuştur.Anahtar kelimeler: Alopesi areata, aile işlevselliği, yaşam kalitesi, psikopatoloji, çocuk ve ergen ABSTRACT Objective: To examine family functioning, psychopathology, quality of life in children and adolescents diagnosed with alopecia areata (AA), and to investigate the relationship between sociodemographic and disease-related variables. Method: 45 patients from 2 to 18 years of age were examined retrospectively. The Family Assessment Device (FAD), the Pediatric Quality of Life Inventory (PedsQL), the Children Depression Inventory (CDI) and the sociodemographic data sheet were used. Statistical analyses were performed using SPSS 18.0 software. Results: Of the subjects assessed, the mean age was 9.22±3.79 and 55.6% were female. The FAD affective involvement and behaviour control subscales demonstrated impairment in the entire case group (>2). 42.2% of the cases received at least one psychiatric diagnosis. Presence of psychiatric comorbidity caused impairment in all the subscales of depression, FAD general functioning, parental quality of life psychosocial health, and pediatric quality of life. A psychosocial trigger incident was detected in 51.1% of the cases. In cases, however, where no trigger incident was detected, CDI and PedsQL showed significant impairment in all the subscales (p<0.05). Lesion intensity was found positively associated only with the number of attacks and duration of the disease. Conclusion: Family functioning in AA patients is impaired in the subscales of affective involvement and behaviour control. Alt...

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Section: Bulgularunclassified

“…Dermatoloji pratiğinde karşılaşılan tüm dermatozların %0,7 ile %3,8'ini oluşturur. Yaşam boyu ortaya çıkabilme riskinin %1,7-%2 olduğu tahmin edilmektedir (1,2) . Her yaş grubunda görülebilirken, olguların %20'si çocuktur.…”

Section: Introductionunclassified

Family functioning, psychopathology and quality of life in children and adolescents with alopecia areata

Kutlu¹,

Kundak²

2016

BUCH

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“…Pomimo niemałej częstości występowania na świecie (0,1-0,2%) i dużej częstości u pacjentów dermatologicznych (0,7-3,8%) procesy patofizjologiczne, które prowadzą do wystąpienia i rozwoju choroby, nie zostały dotychczas wyjaśnione [1][2][3][4]. Wśród możliwych przyczyn wymienia się stres, czynniki infekcyjne, szczepienia, czynniki hormonalne i genetyczne, chociaż wielu autorów uważa, że ujawnienie się choroby oraz jej kliniczne nasilenie zależy prawdopodobnie od współwystępowania wielu czynników etiologicznych [1][2][3]. Dane z ostatnich lat wydają się potwierdzać wcześniejsze sugestie o znacznym udziale procesów autoimmunologicznych w rozwoju tej choroby.…”

Section: Introductionunclassified

“…Dane z ostatnich lat wydają się potwierdzać wcześniejsze sugestie o znacznym udziale procesów autoimmunologicznych w rozwoju tej choroby. Wiele obserwacji podtrzymuje ten pogląd, między innymi obecność w surowicy pacjentów autoprzeciwciał skierowanych przeciw antygenom mieszków włosowych, współwystępowanie innych chorób autoimmunologicznych, jak również poprawa po zastosowaniu leków immunosupresyjnych [2][3][4]. W obrębie i wokół mieszków włosowych w ogniskach łysienia stwierdza się nacieki zapalne złożone głównie z limfocytów Th1, a także wzmożoną ekspresję produkowanych przez te komórki cytokin prozapalnych, w tym interleukiny 2 i 1 (IL-2, IL-1) oraz interferonu γ (IFN-γ) [2][3][4].…”

Section: Introductionunclassified

The role of vitamin D in alopecia areata

Chyl-Surdacka¹,

Gerkowicz²,

Chodorowska³

2016

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Przegląd Dermatologiczny 2016/2 StreSzczenieŁysienie plackowate jest chorobą zapalną charakteryzującą się niebliznowaciejącą utratą włosów, której patogeneza, pomimo częstego występowania u pacjentów dermatologicznych, nie została dostatecznie poznana. Ostatnio podkreśla się udział procesów autoimmunologicznych, na co wskazuje obecność autoprzeciwciał skierowanych przeciw antygenom mieszków włosowych, a także nacieki zapalne ze wzmożo-ną ekspresją cytokin w otoczeniu mieszka. Witamina D spełnia wiele ważnych funkcji w organizmie człowieka -odpowiada za utrzymanie prawidłowej homeostazy wapnia, jest także ważnym regulatorem odpowiedzi immunologicznej. Jej działanie odbywa się głównie za pośrednictwem jądrowego receptora zlokalizowanego na powierzchni komórek dendrytycznych, makrofagów, limfocytów B, limfocytów T, keratynocytów oraz na komórkach brodawki mieszka włosowego. Witamina D działa supresyjnie na komórki układu immunologicznego, a jej niedobór może mieć znaczenie w procesach patofizjologicznych łysienia plackowatego. Dotychczasowe dane sugerują, że suplementacja witaminą D 3 jest wartą rozważenia opcją terapeutyczną u chorych na łysienie plackowate. AbStrActAlopecia areata is an inflammatory disease with noncicatricial hair loss. Despite its high prevalence in the dermatological patient population, the pathogenesis is not sufficiently understood. In recent years, the contribution of autoimmune processes has been emphasized, as indicated by the presence of autoantibodies against hair follicle antigens and inflammatory cell infiltrates with increased expression of cytokines around the hair follicle. Vitamin D performs many important functions in the human body -is responsible for maintaining calcium homeostasis but is also an important regulator of the immune response. It acts mainly via the nuclear vitamin D receptor located on the surface of dendritic cells, macrophages, B and T cells, keratinocytes and cells of the hair follicle papillae. Vitamin D suppresses the immune system cells, and its deficiency may be important in pathophysiological phenomena in alopecia areata. According to current data, vitamin D supplementation may be a therapeutic option worth considering in patients with alopecia areata.

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“… AA (Alopecia areata) is the most frequent cause of inflammation-induced hair loss, affecting 0.1 to 0.2% of population worldwide [1]. Despite its prevalence, there is little known about the underlying etiology and pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Presence of Alternaria in Scalp of Patients with Alopecia Areata: Triggering Factor or Coexistence?

Gaber¹,

Mohamed²,

Gaber³

2015

JLS

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AA (Alopecia areata) is the most frequent cause of inflammation-induced hair loss, affecting 0.1 to 0.2% of population worldwide. The development of organ-specific autoimmune reactions directed against anagen hair follicles seems to play a key role in the pathogenesis of alopecia areata. However, the triggering antigen(s) responsible for inducing autoimmune phenomena in these individuals remain unknown. Viral, bacterial or fungal pathogens have been implied as possible triggering factors of autoimmune reactions. The present study aims to identify the role of dematiaceous fungi in the pathogenesis of alopecia areata. 30 patients diagnosed clinically as alopecia areata and 30 normal age matched persons have undergone mycological examination. Mycology examination of the epidermal scrapings was done by DME (direct microscopic examination), culture on SDA (sabouraud's dextrose agar) and imaging. There is significantly higher percentage of positive results for Alternaria species by culture on sabouraud's agar in patients group (20%) compared to controls (13.3%) P-value < 0.05. The possible role of Alternaria antigens (e.g. antigens involved in melanin synthesis) in triggering autoimmunity in alopecia areata still needs further research on a wider scale of cases.

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Alopecia areata update

Cited by 410 publications

References 97 publications

Family functioning, psychopathology and quality of life in children and adolescents with alopecia areata

Family functioning, psychopathology and quality of life in children and adolescents with alopecia areata

The role of vitamin D in alopecia areata

Presence of Alternaria in Scalp of Patients with Alopecia Areata: Triggering Factor or Coexistence?

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