“…As Piccolo et al suggest, this case is an example of immunocompromised cutaneous district (ICD) (3), which refers to a locoregional cutaneous immune dysregulation deriving from a prior damaging event that has made a skin area prone to the local onset of immunity-related eruptions or skin disorders (3). The factors responsible for localized immune dysregulation are multifarious (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and include chronic lymphatic stasis, herpetic infections, ionizing or ultraviolet radiation, burns, trauma (especially amputation), tattooing, intradermal vaccinations (as happened in this case), and others of disparate nature.…”