Dermatological and immunological conditions due to nerve lesions

Abstract

SummarySome syndromes are of interest to both neurologists and dermatologists, because cutaneous involvement may harbinger symptoms of a neurological disease. The aim of this review is to clarify this aspect. The skin, because of its relationships with the peripheral sensory nervous system, autonomic nervous system and central nervous system, constitutes a neuroimmunoendocrine organ. The skin contains numerous neuropeptides released from sensory nerves. Neuropeptides play a precise role in cutaneous physiology and pathophysiology, and in certain skin diseases. A complex dysregulation of neuropeptides is a feature of some diseases of both dermatological and neurological interest (e.g. cutaneous and nerve lesions following herpes zoster infection, cutaneous manifestations of carpal tunnel syndrome, trigeminal trophic syndrome). Dermatologists need to know when a patient should be referred to a neurologist and should consider this option in those presenting with syndromes of unclear etiology.

Varicella within a Prior Immunization Reaction Site: Another Example of “Isovaccinetopic Response”

“…As Piccolo et al suggest, this case is an example of immunocompromised cutaneous district (ICD) (3), which refers to a locoregional cutaneous immune dysregulation deriving from a prior damaging event that has made a skin area prone to the local onset of immunity-related eruptions or skin disorders (3). The factors responsible for localized immune dysregulation are multifarious (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and include chronic lymphatic stasis, herpetic infections, ionizing or ultraviolet radiation, burns, trauma (especially amputation), tattooing, intradermal vaccinations (as happened in this case), and others of disparate nature.…”

Two novel mutations of the ADAR1 gene in Chinese patients with dyschromatosis symmetrica hereditaria successfully treated with fractional CO2 laser

“…2 The injuring events capable of rendering a skin region a potential ICD are various, numerous, and most of the times identifiable by means of a careful clinical history. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] An ample documentation of multifarious disorders (infectious, neoplastic, immune) appearing in ICDs was delineated by Ruocco et al in 2009. 2 In the following 8 years, what was a novel pathogenic concept has been extended to an enlarging variety of clinical conditions.…”

Hidradenitis suppurativa associated with squamous cell carcinoma: an example of an isoscartopic response

“…In our opinion, the concept of the ICD may represent the key by which this case should be read and may thus represent an additional mechanism for the development of SCC. The causes of trauma capable of rendering a skin region a potential ICD are various, numerous, and usually identifiable by means of a careful clinical history . An ample documentation of multifarious disorders (infectious, neoplastic, immune) appearing in ICDs was delineated by Ruocco et al .…”