Varicella within a Prior Immunization Reaction Site: Another Example of “Isovaccinetopic Response”

Evaluation of skin disorders of lower limb amputation sites: is there a common denominator?

“…All the conditions causing lower limb amputation have a common denominator: they lead to locally hampered lymph drainage (that hinders the normal trafficking of immunocompetent cells) and damage to sensory nerve fibers (that release immunity‐related peptides), or both conditions . Depending on which of the neurotransmitters and immune cells are involved, this destabilization could be either defective, thus predisposing to infections and tumors, or excessive, thus favoring the occurrence of some immune disorders or dysimmune reactions at the sites ‘marked’ by amputation …”

Herpes compuctorum: a cutaneous infection related to permanent tattoo

“…Tattoos induce to locally hampered lymph drainage (that hinders the normal trafficking of immunocompetent cells) and damage to sensory nerve fibers (that release immunity‐related peptides), or both conditions. Depending on which of the neurotransmitters and immune cells are involved, this destabilization could be either defective, thus predisposing to infections and tumors, or excessive, thus favoring the occurrence of some immune disorders or dysimmune reactions at the sites ‘marked’ by tattoo …”

Hidradenitis suppurativa associated with squamous cell carcinoma: an example of an isoscartopic response

“…In our opinion, the concept of the ICD may represent the key by which this case should be read and may thus represent an additional mechanism for the development of SCC. The causes of trauma capable of rendering a skin region a potential ICD are various, numerous, and usually identifiable by means of a careful clinical history . An ample documentation of multifarious disorders (infectious, neoplastic, immune) appearing in ICDs was delineated by Ruocco et al .…”

“…Over the subsequent 8 years, what was a “novel” pathogenic concept has been extended to include an increasing variety of clinical conditions. A recent classification of isomorphic and isotopic skin reactions proposes a newly coined terminology to indicate each specific cause responsible for the occurrence of an ICD and encompasses additional conditions that had not been defined previously . According to this new categorization, the case reported by Verdelli et al .…”