“…All the conditions causing lower limb amputation have a common denominator: they lead to locally hampered lymph drainage (that hinders the normal trafficking of immunocompetent cells) and damage to sensory nerve fibers (that release immunity‐related peptides), or both conditions . Depending on which of the neurotransmitters and immune cells are involved, this destabilization could be either defective, thus predisposing to infections and tumors, or excessive, thus favoring the occurrence of some immune disorders or dysimmune reactions at the sites ‘marked’ by amputation …”