Dermatologic manifestations of colonic disorders

Abstract

Knowledge of these cutaneous manifestations provides an insight into the state of colonic health. These clues alert the clinician to the potential for life-threatening consequences, which leads to vigilant screening and hopefully earlier diagnosis.

Metastatic Crohn′s disease

“…Nonspecific or reactive skin manifestations include entities like pyoderma gangrenosum, erythema nodosum, and oral aphthae. [4] However, such non-specific manifestations were not observed in the present case.…”

“…Mucocutaneous manifestations occur in up to 44% of patients,[4] but they do not necessarily mirror intestinal involvement[5] akin to our patient, who did not have any intestinal symptoms at any time. CCD can occur in association with or preceding intestinal Crohn's disease.…”

Immunosuppression and sebaceous tumors: A confirmed diagnosis of Muir-Torre syndrome unmasked by immunosuppressive therapy

“…14,15 It is important for dermatologists and dermatopathologists to be familiar with current laboratory screening methods to expedite early diagnosis of MTS. 16,17 Tumors from patients with MTS exhibit widespread MSI that can be measured and has been used to preselect patients for mutation analysis in DNA MMR genes. 14,18 MSI is seen in sebaceous tumors and tumors of the cervix, bowel, and stomach in patients with MTS and HNPCC.…”

Granulomatous vasculitis in Crohn's disease: a clinicopathologic correlate of two unusual cases

“…Non‐genital involvement is characterized by ulcerated and non‐ulcerated plaques, nodules, papules and pustules 2,4,9 . Management of ECD is largely empiric and has included metronidazole, oral and topical steroids, azathioprine, cyclosporine, sulfasalazine, 6‐mercaptopurine, infliximab, dapsone and tetracyclines, as well as surgery 4,10 …”