Dermatoglyphic anomalies and neurocognitive deficits in sibling pairs discordant for schizophrenia spectrum disorders

The association of lifetime insight and cognition in psychosis

“…Patients who were affected by DSM-IV schizophrenia spectrum disorders (APA, 1994) were recruited from consecutive admissions to the Psychiatric Unit of Virgen del Camino Hospital in Pamplona, Spain; the admissions were due to psychotic exacerbations. The original sample has been described elsewhere (Rosa et al, 2004(Rosa et al, , 2005.…”

Fluctuating dermatoglyphic asymmetries in youth at ultrahigh-risk for psychotic disorders

“…The present results are consistent with cross sectional investigations in psychosis patients, their healthy relatives and schizotypal individuals that have noted null results in terms of the relationship between fluctuating dermatoglyphic asymmetries and symptoms (Chok et al, 2005; Compton and Walker, 2009; Gabalda and Compton, 2010; Mittal and Walker, 2011). However, other cross sectional studies have found associations between palmar dermatoglyphic asymmetries and negative symptoms in schizophrenia patients as well as negative schizotypy in university students (Páez et al, 2001; Rosa et al, 2005). One explanation is that previous work in schizophrenia patients notes a large amount of heterogeneity in examining dermatoglyphic abnormalities (Golembo-Smith et al, 2012).…”

“…Cross sectional studies of family members with a relative or twin with schizophrenia and young adults with schizotypal personality disorder provide substantial evidence for fluctuating asymmetry in those at risk for psychosis (Gabalda and Compton, 2010; Markow and Gottesman, 1989; Mittal et al, 2012; Rosa et al, 2005). Given that dermatoglyphics represent an intersection between the intrauterine environment and genetic factors, these features hold significant promise for biomarker development.…”

Les signes prédictifs annonciateurs d'une schizophrénie

“…Pour Tarrant et Jones, ces signes neurologiques mineurs peuvent être considérés comme un marqueur-trait de vulnérabilité, témoignant d'un dysfonctionnement cérébral, mais sans valeur prédictive sur l'évolution des sujets [111]. À l'inverse, les anomalies des dermatoglyphes, et notamment leur plus grande asymétrie, semblent être plus spécifiquement observées chez les sujets schizophrènes [103,111].…”