Dermatofibrosarcoma Protuberans with Pulmonary Metastasis in the Absence of Local Recurrence

Kim, Sue Min; Rha, Eun Young; Jung, Sung No; Lim, Jin Soo; Yoo, Gyeol

doi:10.5999/aps.2012.39.3.265

Cited by 8 publications

(15 citation statements)

References 5 publications

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“…Immunohistochemically, the fibrosarcomatous cells will be positive for vimentin, PDGFR, negative for S100, SMA, CD117, DOG1, TLE1,Ki67. DFSP-FS shows remarkably diminished or absent CD34 immunoreactivity 5 6…”

Section: Discussionmentioning

confidence: 97%

“…Among the various histological subtypes, DFSPs with DFSP-FS areas may have a more likelihood of adverse outcomes. DFSP-FS tends to have higher proliferative activity than DFSP without FS area and hence has metastatic potential 5. In all excised lesions, that is, the primary lesion, and the metastatic lesion in the pancreas, have a fibrosarcomatous area, herringbone pattern, and a high number of mitoses (10 mitoses per 10 high-power fields) 5.…”

Section: Discussionmentioning

confidence: 99%

“…DFSP-FS tends to have higher proliferative activity than DFSP without FS area and hence has metastatic potential 5. In all excised lesions, that is, the primary lesion, and the metastatic lesion in the pancreas, have a fibrosarcomatous area, herringbone pattern, and a high number of mitoses (10 mitoses per 10 high-power fields) 5. Immunohistochemically, the fibrosarcomatous cells will be positive for vimentin, PDGFR, negative for S100, SMA, CD117, DOG1, TLE1,Ki67.…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic metastasis of dermatofibrosarcoma protuberans: a rare case

et al. 2020

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Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue malignancy which is locally aggressive, slow growing. It has a very low metastatic potential and has high risk of local recurrence. We report a 65-year-old man with recurrent DFSP of thigh with pancreatic metastasis. Apart from our patient, only four other cases of pancreatic metastasis of DFSP have been reported. Our patient had a solitary metastasis to pancreas and was treated with distal pancreaticosplenectomy. Outcome of the patient was good. We present this case report to emphasise that resection may be considered for solitary metastasis of DFSP and can be managed successfully.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pancreatic metastasis of dermatofibrosarcoma protuberans: a rare case

et al. 2020

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“…In addition, accurate clinicopathologic diagnosis of masses occurring in deep tissue is important because malignant tumors such as dermatofibrosarcoma protuberans may metastasize. 4 Even visceral dermatofibromas may metastasize; according to Gleason and Fletcher,5 there have been 2 reported deaths due to metastasis of visceral dermatofibromas.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Dermatofibroma of the Cheek

Shim

Kwon

et al. 2014

Journal of Craniofacial Surgery

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Dermatofibroma, also known as benign fibrous histiocytoma, is a benign tumor composed of fibroblastic and histiocytic cells. Dermatofibroma most frequently occurs in the dermis, but it can also be found in subcutaneous soft tissue in rare cases, particularly on the face. Herein, we report a case of pure subcutaneous dermatofibroma of the cheek, which was confirmed histopathologically with immunohistochemical staining. This report describes a pure subcutaneous dermatofibroma with a literature review and reminds surgeons to consider the possibility that dermatofibromas may occur in the subcutaneous layer before establishing their operative plan.

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“…Metastases occur only in 0.5-5% of the cases, usually after repeated local recurrences, being the most common sites lung, bones and regional lymph nodes. 3 …”

Section: Introductionmentioning

confidence: 99%

Dermatofibrosarcoma Protu-Berans with Lung Metastasis Requiring Pneumonectomy

et al. 2015

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We report the case of a young man diagnosed with dermatofibrosarcoma protuberans lung metastases seven years after primary tumor resection. Notably, no previous local recurrences had been observed. A multimodal approach was used for the management of this patient: surgery, radiotherapy and targeted therapy with Imatinib. The patient is alive with stable disease after thirty months of the metastases diagnoses. Dermatofibrosarcoma protu-berans metastasizes very rarely, and when it does, it is usually either after local recurrence or whenever fibrosarcomatous transformation is found in the histopathological analysis, which confers an increased risk of local recurrence and metastases. This is the second report of a metastatic dermatofibrosarcoma protuberans occurring in a patient with no previous local recurrence or histological fibrosar-comatous features, emphasizing the rarity of the disease presentation and the importance of targeted therapy in improving patient quality of life and survival.

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Dermatofibrosarcoma Protuberans with Pulmonary Metastasis in the Absence of Local Recurrence

Cited by 8 publications

References 5 publications

Pancreatic metastasis of dermatofibrosarcoma protuberans: a rare case

Pancreatic metastasis of dermatofibrosarcoma protuberans: a rare case

Subcutaneous Dermatofibroma of the Cheek

Dermatofibrosarcoma Protu-Berans with Lung Metastasis Requiring Pneumonectomy

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