Subcutaneous Dermatofibroma of the Cheek

Abstract

Dermatofibroma, also known as benign fibrous histiocytoma, is a benign tumor composed of fibroblastic and histiocytic cells. Dermatofibroma most frequently occurs in the dermis, but it can also be found in subcutaneous soft tissue in rare cases, particularly on the face. Herein, we report a case of pure subcutaneous dermatofibroma of the cheek, which was confirmed histopathologically with immunohistochemical staining. This report describes a pure subcutaneous dermatofibroma with a literature review and reminds surgeons to consider the possibility that dermatofibromas may occur in the subcutaneous layer before establishing their operative plan.

Uncommon Presentation of Benign Dermatofibroma of Thigh: A Case Report

“…The patient denied noticing a palpable nodule or papule on her leg, she further denied any history of trauma, insect bites, or known irritation to the area. This presentation differs from other reported case reports of DF where nodules have been visible on clinical presentation 1,3,4 or associated with known insect bites or trauma. 2,4 .…”

“…The DF was visualized under 20x and 40x magnification and found to be solely within the dermis layer, as is most often the case. 1 Visualization of the lesion revealed the presence of fibrous spindle cells and histiocytes (Figure 7). Due to lack of infiltration into subcutaneous fat, 5 dermatofibrosarcoma protuberans was ruled out as a possible etiology for this sample.…”

“…Dermatofibroma refers to a benign tumor that is often found in the dermis and rarely in the subcutaneous layer of the skin. 1,7 DFs, or histiocytomas as they are sometimes called, 2 are most often found in the trunk and extremities and are more common in women and middle-aged individuals. 1 The etiology of DF is still being debated, but several possible mechanisms are suggested including that of trauma, ruptured hair follicle, or insect bite-induced.…”

“…They are most often found in the dermis layer of skin and are composed of a variety of histiocytes. 1 The histological and clinical presentations of DF can differ widely as it has been noted to clinically present as a nodule, papule, or plaque. 2 Further, DF can have a wide variety of histological presentations due to the different compositions of inflammatory cell types and stromal cells.…”

A Rare Localization of Subcutaneous Dermatofifibroma: Case Report

“…3 It is rarely seen in the muscle and subcutaneous regions. 2 The origin of the tumor is thought to be the histiocyte. 3 Definitive diagnosis is made by histopathological examination following the total excision.…”