2019
DOI: 10.1590/abd1806-4841.20198227
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Dermatitis herpetiformis in an adolescent patient

Abstract: Dermatitis herpetiformis is a pruritic, blistering skin disease affecting the extensor surface of the limbs, the buttocks and lower back. The autoantigen involved is transglutaminase-3, an enzyme of epidermis. 1 The diagnosis is confirmed by direct immunofluorescence of perilesional skin, with a pathognomonic pattern of granular IgA deposits in papillary dermis, with a false-negative rate of 5%.

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Cited by 6 publications
(5 citation statements)
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“…When it comes to symptomatology of the disease in later childhood and adolescence, mono or oligosymptomatic extraintestinal manifestations are dominant (16). In addition to the manifestations seen in preschool age, there are others, such as maturation delay, enamel hypoplasia, recurrent aphthous stomatitis, chronic malaise, dermatitis herpetiformis, osteopenia, arthralgia, myalgia, cerebellar ataxia, polyneuropathy, epilepsy, and others (3,6,16,22,34).…”
Section: Clinical Forms Of the Diseasementioning
confidence: 99%
“…When it comes to symptomatology of the disease in later childhood and adolescence, mono or oligosymptomatic extraintestinal manifestations are dominant (16). In addition to the manifestations seen in preschool age, there are others, such as maturation delay, enamel hypoplasia, recurrent aphthous stomatitis, chronic malaise, dermatitis herpetiformis, osteopenia, arthralgia, myalgia, cerebellar ataxia, polyneuropathy, epilepsy, and others (3,6,16,22,34).…”
Section: Clinical Forms Of the Diseasementioning
confidence: 99%
“…However, DH incidence seems in reduction, differently from the four-fold increase detected in the incidence of CD (98). DH is typical of adulthood; however DH can be also diagnosed in childhood and in adolescence (99)(100)(101). While a female prevalence is reported in CD, previous studies on DH showed a male to female ratio ranging from 1.1 to 1.9 (102).…”
Section: Dermatitis Herpetiformis: Typical and Atypical Manifestationsmentioning
confidence: 99%
“…Assim, ambas são mediadas imunologicamente por anticorpos IgA, apresentam intolerância ao glúten e evoluem positivamente em resposta a uma dieta sem glúten. (COSTIN et al, 2019). Além disso, todos os pacientes com DH apresentam lesão consistente com DC ou ao menos algum grau de inflamação da mucosa intestinal (COLLIN et al, 2003).…”
Section: Fisiopatologia Da Dermatite Herpetiformeunclassified