Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Frederiksen, Marie; Stapleton, Heather M.; Vorkamp, Katrin; Webster, Thomas F.; Jensen, Niels Martin; Sørensen, Jens Ahm; Nielsen, Flemming; Knudsen, Lisbeth E.; Sørensen, Lene Tolstrup; Clausen, Per Axel; Nielsen, Julius

doi:10.1016/j.chemosphere.2018.01.032

Cited by 46 publications

(20 citation statements)

References 39 publications

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“…While exposure to PFRs have been generally accepted to be via inhalation and dermal absorption, the same has not been the case for PBDEs. 71–75 Therefore, wristbands may have the potential to be used in examining the dermal absorption pathway for a large range of SVOCs, which has largely been underestimated in exposure assessment.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Hammel

Phillips

Hoffman

et al. 2018

Environ. Sci. Technol.

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Biomarkers remain the gold standard for assessing chemical exposure. However, silicone wristbands may provide some added benefits for characterizing personal exposures compared to single biomarker measurements, such as decreased costs, noninvasive sampling, and increased ease of analysis. Previously, we validated their use in characterizing exposure to organophosphate flame retardants (PFRs). However, it is unclear whether these results would extend to chemicals like polybrominated diphenyl ethers (PBDEs), which biomagnify and have longer half-lives than PFRs in the body. This study sought to determine if accumulation of PBDEs on wristbands was correlated to serum biomarkers. Adult participants ( n = 30) provided serum samples and wore wristbands for 7 days. PBDEs and 6 novel brominated flame retardants (BFRs) were measured on wristbands, and serum samples were analyzed for PBDE biomarkers. Like most PBDE congeners, 5 of 6 novel BFRs were frequently detected on wristbands (≥90% of bands). In particular, decabromodiphenyl ethane (DBDPE) was detected in all wristbands in this study and was significantly correlated with BDE-209, suggesting a similar source and exposure pathway. Wristband levels of BDE-47, -99, -100, and -153 were significantly and positively associated with respective serum biomarkers ( r = 0.39-0.57, p < 0.05). This study demonstrates that silicone wristbands can accurately detect personal PBDE exposures.

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Section: Resultsmentioning

confidence: 99%

Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Hammel

Phillips

Hoffman

et al. 2018

Environ. Sci. Technol.

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“…Because OPEs have been shown to act on similar endocrine signaling endpoints, which can affect body weight regulation, the period of pregnancy may represent a vulnerable period of exposure for OPE modulation of body weight. However, it is possible that increased body size may lead to increased OPE exposure via larger surface area for dermal absorption of OPEs or dietary patterns [21,[60][61][62]. Therefore, further research is needed to determine causality, as well as to confirm the suggestive positive relationship between OPE exposure and GWG in a larger study population.…”

Section: Discussionmentioning

confidence: 99%

Maternal urinary concentrations of organophosphate ester metabolites: associations with gestational weight gain, early life anthropometry, and infant eating behaviors among mothers-infant pairs in Rhode Island

et al. 2020

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Background Organophosphate esters (OPEs)—used as flame retardants and plasticizers—are associated with adverse pregnancy outcomes such as reduced fecundity and live births and increased preterm delivery. OPEs may interfere with growth and metabolism via endocrine-disruption, but few studies have investigated endocrine-related outcomes. The objective of this pilot study (n = 56 mother-infant pairs) was to evaluate associations of OPEs with gestational weight gain (GWG), gestational age at delivery, infant anthropometry, and infant feeding behaviors. Methods We quantified OPE metabolites (bis-2-chloroethyl phosphate [BCEP], bis (1,3-dichloro-2-propyl) phosphate [BDCPP], diphenyl phosphate [DPHP]) in pooled maternal spot urine collected throughout pregnancy (~ 12, 28, and 35 weeks’ gestation). We obtained maternal sociodemographic characteristics from questionnaires administered at enrollment and perinatal characteristics from medical record abstraction. Trained research assistants measured infant weight, length, head and abdominal circumferences, and skinfold thicknesses at birth and 6 weeks postpartum. Mothers reported infant feeding behavior via the Baby Eating Behavior Questionnaire (BEBQ). Using multiple linear regression, we assessed associations of log2-transformed maternal urinary OPE metabolites with GWG, gestational age at delivery, infant anthropometry at birth, weekly growth rate, and BEBQ scores at 6 weeks postpartum. We used linear mixed effects (LME) models to analyze overall infant anthropometry during the first 6 weeks of life. Additionally, we considered effect modification by infant sex. Results We observed weak positive associations between all OPE metabolites and GWG. In LME models, BDCPP was associated with increased infant length (β = 0.44 cm, 95%CI = 0.01, 0.87) and weight in males (β = 0.14 kg, 95%CI = 0.03, 0.24). BDCPP was also associated with increased food responsiveness (β = 0.23, 95%CI = 0.06, 0.40). DPHP was inversely associated with infant abdominal circumference (β = − 0.50 cm, 95%CI = − 0.86, − 0.14) and female weight (β = − 0.19 kg, 95%CI = − 0.36, − 0.02), but positively associated with weekly growth in iliac skinfold thickness (β = 0.10 mm/wk., 95%CI = 0.02, 0.19). Further, DPHP was weakly associated with increased feeding speed. BCEP was associated with greater infant thigh skinfold thickness (β = 0.34 mm, 95%CI = 0.16, 0.52) and subscapular skinfold thickness in males (β = 0.14 mm, 95%CI = 0.002, 0.28). Conclusions Collectively, these findings suggest that select OPEs may affect infant anthropometry and feeding behavior, with the most compelling evidence for BDCPP and DPHP.

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“…More recently, hand wipes have been used to characterize human exposure to FRs, and have been shown to be have potential as an exposure metric for OPEs in particular (Hoffman et al, 2015; Stapleton et al, 2014; Watkins et al, 2011). In addition, in vitro findings demonstrate that dermal absorption likely plays a role in the exposure pathway for OPEs (Abou-Elwafa Abdallah et al, 2016; Frederiksen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Children's residential exposure to organophosphate ester flame retardants and plasticizers: Investigating exposure pathways in the TESIE study

Phillips

Hammel

Hoffman

et al. 2018

Environment International

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136

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Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Cited by 46 publications

References 39 publications

Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Maternal urinary concentrations of organophosphate ester metabolites: associations with gestational weight gain, early life anthropometry, and infant eating behaviors among mothers-infant pairs in Rhode Island

Children's residential exposure to organophosphate ester flame retardants and plasticizers: Investigating exposure pathways in the TESIE study

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