Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Hammel, Stephanie C.; Phillips, Allison L.; Hoffman, Kate; Stapleton, Heather M.

doi:10.1021/acs.est.8b03755

Cited by 68 publications

(101 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, the geometric mean of BDE-47, -99, and -209 measured in this study (6.21, 3.67, and 3.71 ng/g wristband, respectively), were lower than those measured in adults in North Carolina (55.9, 35.4, and 12.2 ng/g wristband, respectively) [13]. However, the geometric mean of BEHTBP in this study (27.3 ng/g wristband) was comparable to BEHTBP geometric mean (32.6 ng/g wristband) measured in adults in North Carolina [13].…”

Section: Application To Deployed Wristband Samplescontrasting

confidence: 75%

“…Our average EHTBB and BEHTBP concentrations of 22.7 and 35.1 ng/g wristband, respectively, were comparable with the previously reported EHTBB and BEHTBP concentrations among Oregon children (41.7 and 71.4 ng/g wristband, respectively) [4]. Further, the geometric mean of BDE-47, -99, and -209 measured in this study (6.21, 3.67, and 3.71 ng/g wristband, respectively), were lower than those measured in adults in North Carolina (55.9, 35.4, and 12.2 ng/g wristband, respectively) [13]. However, the geometric mean of BEHTBP in this study (27.3 ng/g wristband) was comparable to BEHTBP geometric mean (32.6 ng/g wristband) measured in adults in North Carolina [13].…”

Section: Application To Deployed Wristband Samplescontrasting

confidence: 60%

“…Chromatographic cleanup procedures previously used for analysis of organic pollutants in wristbands include Florisil [12], C 18 solid phase extraction cartridges [4], and 5% acid silica columns [13]. Some other methods (mostly focusing on the screening of analytes) did not include any cleanup or fractionation [5,7,14].…”

Section: Chromatographic Cleanupmentioning

confidence: 99%

“…These studies have demonstrated that a commercial silicone wristband, worn by study participants, offers a non-invasive and simple way to quantify personal exposure to multiple chemicals from multiple microenvironments and within a multiday time period. Further, several studies have found significant correlations between the mass of chemicals accumulated on the wristband and biomarkers of internal exposure measured in blood or urine [11][12][13]. This sampling method opens a wide range of opportunities for larger scale exposure monitoring studies, especially in vulnerable populations such as children, due to its noninvasiveness (and thus low rejection rates of subject participation), simplicity, and cost-effectiveness.…”

Section: Introductionmentioning

confidence: 99%

“…To date, silicone wristbands have been employed in a small number of studies to measure polycyclic aromatic hydrocarbons (PAHs) [5], polybrominated diphenyl ethers (PBDEs) and novel flame retardants (NFRs) [4,13], organophosphate esters (OPEs) [12], and pesticides [6,9]. However, these previous studies on wristbands were limited to one group of compounds or to qualitative analysis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Analysis of brominated and chlorinated flame retardants, organophosphate esters, and polycyclic aromatic hydrocarbons in silicone wristbands used as personal passive samplers

Romanak

Wang

Stubbings

et al. 2019

Journal of Chromatography A

View full text Add to dashboard Cite

For the first time, we present an analytical method to simultaneously extract, fractionate, and quantify four groups of semi-volatile organic compounds (SVOCs) in silicone wristbands, including 35 polybrominated diphenyl ethers (PBDEs), 10 novel flame retardants (NFRs), 19 organophosphate esters (OPEs), and 13 polycyclic aromatic hydrocarbons (PAHs). Wristbands were extracted using ultrasonication, and cleaned and fractionated on two multi-layer columns: one consisting of neutral alumina, neutral silica and Florisil, and the other consisting of neutral alumina, neutral silica, and acidic silica. Method accuracy and precision were validated using spiked wristband samples (n = 8) and procedural blanks (n = 7). Average matrix spike percent recoveries for all target analytes were within 57 -107% with relative standard errors < 20%, with a few exceptions. This method was applied to analyze thirteen wristbands worn by ten participants for seven days; three participants wore two wristbands to evaluate duplicate samples. Percent recoveries of surrogate standards for all four groups of analytes in these wristbands were all within the 80 -120% range with a few exceptions: recoveries for 13 C 12 BDE-209 and for 13 C 12 -triphenyl phosphate ranged from 35 -62% and 69 -176%, respectively. The majority of target analytes were detected in at least half of worn wristbands. The levels of total PBDEs, NFRs, OPEs and PAHs in deployed wristbands ranged from 28.4 to 412 ng, 40.7 to 625 ng, 2,440 to 9,580 ng, and 76.2 to 1,240 ng, respectively.We developed an efficient method for the determination of a total of 77 analytes, including 35 PBDEs, 10 NFRs, 19 OPEs, and 13 PAHs, in silicone wristbands. This method offers a solution to chromatographic interferences associated with siloxanes from the wristband Romanak et al. Highlights •Silicone wristbands are a novel tool for assessing personal exposures • This is the first method for simultaneous quantitative analysis of 77 SVOCs 35 PBDEs, 9 NFRs, 19 OPEs, and 13 PAHs were simultaneously extracted and analyzed Romanak et al. •

show abstract

Section: Application To Deployed Wristband Samplescontrasting

confidence: 75%

Section: Application To Deployed Wristband Samplescontrasting

confidence: 60%

Section: Chromatographic Cleanupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of brominated and chlorinated flame retardants, organophosphate esters, and polycyclic aromatic hydrocarbons in silicone wristbands used as personal passive samplers

Romanak

Wang

Stubbings

et al. 2019

Journal of Chromatography A

View full text Add to dashboard Cite

show abstract

Comparison of chemical contaminant measurements using CLAM, POCIS, and silicone band samplers in estuarine mesocosms

Wirth,

Shaddrix,

Pisarski

et al. 2024

Integr Envir Assess & Manag

View full text Add to dashboard Cite

Discrete water samples represent a snapshot of conditions at a particular moment in time and may not represent a true chemical exposure caused by changes in chemical input, tide, flow, and precipitation. Sampling technologies have been engineered to better estimate time‐weighted concentrations. In this study, we consider the utility of three integrative sampling platforms: polar organic chemical integrative sampler (POCIS), silicone bands (SBs), and continuous, low‐level aquatic monitoring (CLAM). This experiment used simulated southeastern salt marsh mesocosm systems to evaluate the response of passive (POCIS, SBs) and active sampling (CLAM) devices along with discrete sampling methodologies. Three systems were assigned to each passive sampler technology. Initially, all tanks were dosed at nominal (low) bifenthrin, pyrene, and triclosan concentrations of 0.02, 2.2, and 100 µg/L, respectively. After 28 days, the same treatment systems were dosed a second time (high) with bifenthrin, pyrene, and triclosan at 0.08, 8.8, and 200 µg/L, respectively. For passive samplers, estimated water concentrations were calculated using published or laboratory‐derived sampling rate constants. Chemical residues measured from SBs resulted in high/low ratios of approximately 2x, approximately 3x, and 1x for bifenthrin, pyrene, and triclosan. A similar pattern was calculated using data from POCIS samples (~4x, ~3x, ~1x). Results from this study will help users of CLAM, POCIS, and SB data to better evaluate water concentrations from sampling events that are integrated across time. Integr Environ Assess Manag 2024;00:1–12. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

show abstract

Optimized workflow for unknown screening using gas chromatography high‐resolution mass spectrometry expands identification of contaminants in silicone personal passive samplers

Travis

Kordas

Aga

2021

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

Rationale Silicone wristbands have emerged as valuable passive samplers for monitoring of personal exposure to environmental contaminants in the rapidly developing field of exposomics. Once deployed, silicone wristbands collect and hold a wealth of chemical information that can be interrogated using high‐resolution mass spectrometry (HRMS) to provide a broad coverage of chemical mixtures. Methods Gas chromatography coupled to Orbitrap™ mass spectrometry (GC/Orbitrap™ MS) was used to simultaneously perform suspect screening (using in‐house database) and unknown screening (using vendor databases) of extracts from wristbands worn by volunteers. The goal of this study was to optimize a workflow that allows detection of low levels of priority pollutants, with high reliability. In this regard, a data processing workflow for GC/Orbitrap™ MS was developed using a mixture of 123 environmentally relevant standards consisting of pesticides, flame retardants, organophosphate esters, and polycyclic aromatic hydrocarbons as test compounds. Results The optimized unknown screening workflow using a search index threshold of 750 resulted in positive identification of 70 analytes in validation samples, and a reduction in the number of false positives by over 50%. An average of 26 compounds with high confidence identification, 7 level 1 compounds and 19 level 2 compounds, were observed in worn wristbands. The data were further analyzed via suspect screening and retrospective suspect screening to identify an additional 36 compounds. Conclusions This study provides three important findings: (1) a clear evidence of the importance of sample cleanup in addressing complex sample matrices for unknown analysis, (2) a valuable workflow for the identification of unknown contaminants in silicone wristband samplers using electron ionization HRMS data, and (3) a novel application of GC/Orbitrap™ MS for the unknown analysis of organic contaminants that can be used in exposomics studies.

show abstract

Evaluating the Use of Silicone Wristbands To Measure Personal Exposure to Brominated Flame Retardants

Cited by 68 publications

References 73 publications

Analysis of brominated and chlorinated flame retardants, organophosphate esters, and polycyclic aromatic hydrocarbons in silicone wristbands used as personal passive samplers

Analysis of brominated and chlorinated flame retardants, organophosphate esters, and polycyclic aromatic hydrocarbons in silicone wristbands used as personal passive samplers

Comparison of chemical contaminant measurements using CLAM, POCIS, and silicone band samplers in estuarine mesocosms

Optimized workflow for unknown screening using gas chromatography high‐resolution mass spectrometry expands identification of contaminants in silicone personal passive samplers

Contact Info

Product

Resources

About