Dermal Skin Substitutes for Upper Limb Reconstruction

Rehim, Shady A.; Singhal, Maneesh; Chung, Kevin C.

doi:10.1016/j.hcl.2014.02.001

Cited by 53 publications

(24 citation statements)

References 42 publications

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“…The anhydroglucose units and various bacterial cellulose fibrils interact closely with each other to form a crystalline structure through internal and external hydrogen bonds, resulting in the compaction of fibers that are completely insoluble in water but that can be hydrated (Lynd et al 2002;Conley et al 2016) The thin nanofibers have a diameter of 20-100 nm, with a large surface area per unit; this feature, combined with the hydrophilic nature of BNC, results in high water absorption capacity, better adherence, and increased moisture content (Fu et al 2013;Numata et al 2015b). These properties, combined with the distinct physical and mechanical properties of the molecule, including its insolubility, rapid biodegradability, tensile strength, elasticity, durability, and nontoxic and nonallergenic features, make BNC ideal for the production of several products with high added value, such as artificial skin used as a temporary substitute in the treatment of burns and other dermal injuries (Thompson and Hamilton 2001;Rehim et al 2014;Cakar et al 2014).…”

Section: Cellulosementioning

confidence: 99%

Bacterial nanocellulose production and application: a 10-year overview

Jozala

Novaes

Lopes³

et al. 2016

Appl Microbiol Biotechnol

365

212

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Production of bacterial nanocellulose (BNC) is becoming increasingly popular owing to its environmentally friendly properties. Based on this benefit of BNC production, researchers have also begun to examine the capacity for cellulose production through microbial hosts. Indeed, several research groups have developed processes for BNC production, and many studies have been published to date, with the goal of developing methods for large-scale production. During BNC bioproduction, the culture medium represents approximately 30 % of the total cost. Therefore, one important and challenging aspect of the fermentation process is identification of a new cost-effective culture medium that can facilitate the production of high yields within short periods of time, thereby improving BNC production and permitting application of BNC in the biotechnological, medical, pharmaceutical, and food industries. In this review, we addressed different aspects of BNC production, including types of fermentation processes and culture media, with the aim of demonstrating the importance of these parameters.

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Section: Cellulosementioning

confidence: 99%

Bacterial nanocellulose production and application: a 10-year overview

Jozala

Novaes

Lopes³

et al. 2016

Appl Microbiol Biotechnol

365

212

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“…The main matrix components in skin are collagens, elastin, GAGs, laminin, nidogen and fibronectin 78 , and matrices derived from fibroblasts, the primary cell type within the dermis, recapitulate some the main components in adult skin 10, 57, 79 . Acellular dermal matrix allografts and skin substitutes, such as INTEGRA® Dermal Regeneration Template, are routinely used in the clinic to treat burns and chronic wounds 80-83 . However, adult skin is also known to have reduced regenerative capability compared to fetal skin.…”

Section: Embryonic Stem Cell-derived Matricesmentioning

confidence: 99%

Cell-derived matrices for tissue engineering and regenerative medicine applications

2015

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The development and application of decellularized extracellular matrices (ECM) has grown rapidly in the fields of cell biology, tissue engineering and regenerative medicine in recent years. Similar to decellularized tissues and whole organs, cell-derived matrices (CDMs) represent bioactive, biocompatible materials consisting of a complex assembly of fibrillar proteins, matrix macromolecules and associated growth factors that often recapitulate, at least to some extent, the composition and organization of native ECM microenvironments. The unique ability to engineer CDMs de novo based on cell source and culture methods makes them an attractive alternative to conventional allogeneic and xenogeneic tissue-derived matrices that are currently harvested from cadaveric sources, suffer from inherent heterogeneity, and have limited ability for customization. Although CDMs have been investigated for a number of biomedical applications, including adhesive cell culture substrates, synthetic scaffold coatings, and tissue engineered products, such as heart valves and vascular grafts, the state of the field is still at a relatively nascent stage of development. In this review, we provide an overview of the various applications of CDM and discuss successes to date, current limitations and future directions.

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“…A correct knowledge of complications and those factors that may preclude a successful reconstruction using dermal substitutes are mandatory to optimize their use. Common complications of dermal substitutes are infection, hematoma, graft failure, need for multiple procedures 11 or unpredictable matrix thinning with unpleasant aesthetic results in challenging facial defects. 12 …”

Section: Discussionmentioning

confidence: 99%

Reconstruction of Full-thickness Soft Tissue Defects with Integra: Risk Factors and Treatment Algorithm

Scalise

Torresetti

Benedetto

2020

Plastic and Reconstructive Surgery - Global Open

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Background: Despite the fact that dermal substitutes are widely used in reconstructive surgery, there have been no studies focused on predictors of complications or delayed matrix take. We propose an algorithm for management of soft tissue reconstruction with Integra dermal matrix, based on our 5-year-long clinical experience. Methods: An estimated 111 patients who underwent Integra reconstruction of full-thickness soft tissue defects of different anatomical sites and etiology were enrolled, and dichotomized in two groups according to complications. Participants were further studied according to the wound healing strategy: healing by secondary intention, skin graft (STSG), and flap surgery. A regression analysis was conducted in the whole sample to identify possible predictors of complications. Results: No significant differences according to complications were observed. The between-group statistical analysis showed significant differences in age, comorbidities, defect area, diagnosis, and defect site. The regression analysis revealed that the timing of split-thickness skin graft (STSG) was not influenced by age, comorbidities, body mass index (BMI), defect area, site, wound etiology, and risk factors in the subjects who underwent a two-step reconstruction. Healing by secondary intention is recommended for small post-oncological defects of the head, especially in elderly and multimorbid patients. Variables that may interfere with dermal substitutes’ incorporation are independent of the timing of STSG placement; therefore, no predictors of complications or delayed matrix take were identified. Conclusions: Our findings showed that Integra can be used in a wide range of patients regardless of their general features, thus acting as a useful alternative to conventional reconstructive techniques in selected cases.

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Dermal Skin Substitutes for Upper Limb Reconstruction

Cited by 53 publications

References 42 publications

Bacterial nanocellulose production and application: a 10-year overview

Bacterial nanocellulose production and application: a 10-year overview

Cell-derived matrices for tissue engineering and regenerative medicine applications

Reconstruction of Full-thickness Soft Tissue Defects with Integra: Risk Factors and Treatment Algorithm

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