Dermal Sclerosis in the Lesional Skin of ‘Flagellate’ Erythema (Scratch Dermatitis) Induced by Bleomycin

Yamamoto, Toshiyuki; Yokozeki, Hiroo; Nishioka, Kiyoshi

doi:10.1159/000018044

Cited by 12 publications

(8 citation statements)

References 6 publications

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“…To date a number of cases with bleomycin‐induced flagellate erythema have been reported 10–28 . Additionally, an unusual case of reticular and linear hyperpigmentation has been reported 29 .…”

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

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Flagellate erythema

Yamamoto¹,

Nishioka²

2005

Int J Dermatology

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Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

“…A case of flagellate erythema showing histological dermal sclerosis treated with bleomycin with a total dose of 45 mg has been reported 24 . Scleroderma is reported to be developed in patients under systemic bleomycin therapy 35–38 .…”

Section: Bleomycin‐induced Flagellate Erythemamentioning

confidence: 99%

Flagellate erythema

Yamamoto¹,

Nishioka²

2005

Int J Dermatology

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“…2). [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Additionally, an unusual case of reticular and linear hyperpigmentation was reported. 58 The incidence rate was shown to be 8-66% in patients treated with bleomycin.…”

Section: 'Flagellate' Erythemamentioning

confidence: 99%

“…A case of flagellate erythema showing histological dermal sclerosis has also been reported. 54 Rats injected repeatedly with sublethal doses of bleomycin over a 58-week period developed severe dermal fibrosis, with structural abnormalities in the collagen fibres. 81 In mice, repeated local injection of bleomycin induced dermal sclerosis mimicking human scleroderma, and has even been established as a mouse model for scleroderma.…”

Section: Bleomycin-induced Sclerodermamentioning

confidence: 99%

Bleomycin and the skin

Yamamoto

2006

British Journal of Dermatology

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121

111

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Bleomycin is frequently used as a chemotherapeutic agent to treat various kinds of malignancy. However, the cytotoxic effects of bleomycin cause a number of adverse responses, in particular in the lung and the skin. Bleomycin is used by dermatologists as a treatment for various skin cancers, recalcitrant warts, keloid and hypertrophic scars. This article discusses the use of bleomycin for various skin disorders, as well as the risk factors and cutaneous side-effects resulting from its use.

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“…In addition, the cutaneous side effects of BLM include Raynaud's phenomenon, cutaneous fibrosis, acral keratosis, hyperpigmentation, alopecia, gangrene, and scratch-induced dermatitis. [5][6][7][8] BLM-induced pulmonary fibrosis has been established as an experimental animal model for lung fibrosis. 9,10 We recently established a mouse model of scleroderma by repeated local injections of BLM.…”

Section: Introductionmentioning

confidence: 99%

Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma

Yokozeki

Takagawa

et al. 2004

Gene Ther

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Systemic sclerosis (SSc) is a connective tissue disorder with an unknown etiology. There are currently no effective therapies for SSc. (In this study, working with a bleomycin(BLM)-induced scleroderma model mice, we performed two transfections of human hepatocyte growth factor (HGF) cDNA into the skeletal muscle and showed that this treatment not only helped to prevent the dermal sclerosis simultaneously injected BLM but also improved the symptoms of dermal sclerosis induced by BLM 4 weeks previously.) RT-PCR, ELISA and an immunohistochemical analysis revealed that both mRNA and protein of human HGF as well as murine HGF were enhanced in the skin, lung, muscle and the serum after two transfections of human HGF cDNA. These analyses also revealed that this treatment significantly reduced both the expression of the TGF-b1 mRNA and the production of TGF-b1 on macrophage-like cells that infiltrated the dermis and the fibroblastic cells in BLM-induced scleroderma. Furthermore, HGF-gene transfection both prevented and ameliorated the symptoms of not only dermal sclerosis but also of lung fibrosis induced by a subcutaneous BLM injection. These results indicated that gene therapy by the transfection of the human HGF cDNA may thus be a useful therapy for SSc and lung fibrosis involved with SSc.

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Dermal Sclerosis in the Lesional Skin of ‘Flagellate’ Erythema (Scratch Dermatitis) Induced by Bleomycin

Cited by 12 publications

References 6 publications

Flagellate erythema

Flagellate erythema

Bleomycin and the skin

Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma

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