Flagellate erythema

Yamamoto, Toshiyuki; Nishioka, Kiyoshi

doi:10.1111/j.1365-4632.2005.02647.x

Cited by 56 publications

(59 citation statements)

References 51 publications

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“…[6] The pathogenesis of bleomycin dermatitis remains speculative and various theories such as micro-trauma, inflammatory oncotaxis, increased melanogenesis, heat-recall and reduced epidermal turnover allowing prolonged melanocyte-keratinocyte contact have been proposed. [4,7,8] There is no specific treatment, but avoidance of bleomycin leads to eventual clearance over months to years. However, re-exposure may produce an aggravated reaction.…”

Section: Chemotherapy Induced Fl Agellate Dermatitis and Pigmentationmentioning

confidence: 99%

Flagellate dermatoses

Bhushan¹,

Manjul²,

Baliyan³

2014

Indian J Dermatol Venereol Leprol

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Section: Chemotherapy Induced Fl Agellate Dermatitis and Pigmentationmentioning

confidence: 99%

Flagellate dermatoses

Bhushan¹,

Manjul²,

Baliyan³

2014

Indian J Dermatol Venereol Leprol

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“…Differential diagnosis of flagellate erythema includes bleomycin, dermatomyositis, and shiitake mushroom dermatitis. 9 This nonclassic variant also has unique histopathologic features including dyskeratosis in the upper layers of the epidermis extending into the stratum corneum without involvement of the basal layer and a superficial dermal infiltrate with neutrophils and lymphocytes. [4][5][6][7][8] While this nontypical variant was first described by Kaur et al 4 in 1994, it may be an underrecognized cutaneous manifestation of AOSD.…”

mentioning

confidence: 98%

Flagellate Erythema in a Patient With Fever

2013

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A woman in her 40s presented with a 6-month history of intermittent fevers, malaise, polyarthralgias, sore throat, and a pruritic exanthem on her trunk, scalp, and extremities. A previous biopsy was nonspecific. She had no significant medical history.Physical examination revealed erythematous, mildly scaly plaques in a shawl distribution ( Figure, A) and hyperpigmented, erythematous, excoriated papules in a linear arrangement on her back (Figure, B) and lower extremities. Laboratory studies showed leukocytosis (27 900/uL, 95% neutrophils) and increased levels of C-reactive protein (344 mg/L) and ferritin (63 000 ng/mL). Antinuclear antibody titer was 1:80. Findings for rheumatoid factor and antineutrophil cytoplasmic antibodies were negative, as were those for Lyme disease, rickettsial disease, cytomegalovirus, Bartonella, rapid plasma reagin, human immunodeficiency virus, and hepatitis. Serum and urine protein electrophoresis findings were also negative, and chest, abdomen, and pelvic computed tomography showed nonspecific hilar lymphadenopathy. A punch biopsy specimen from the back was obtained (Figure, C).

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“…More specific clinical presentations have been less frequently identified such as serpentine supravenous hyperpigmentation (mainly with 5-fluorouracil) [11,12,13,14] or bleomycin-induced flagellate hyperpigmentation [15,16,17,18,19,20,21]. …”

Section: Introductionmentioning

confidence: 99%

Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature

Regnault

Gadaud²,

Boulinguez

et al. 2015

Dermatology

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Background: Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin. Case Reports: We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review. Conclusion: Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.

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Flagellate erythema

Cited by 56 publications

References 51 publications

Flagellate dermatoses

Flagellate dermatoses

Flagellate Erythema in a Patient With Fever

Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature

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