Dermal Role and Controls in Psoriasis

Psoriasis: Disease of Epidermis or Dermis?

“…These observations lead us to conclude that the expression of psoriasis must depend on some yet unknown factors in the dermis and the epidermis which are necessary for the initiation of psoriasis. This conforms to the view of other works 1,4,6 . More research directed toward identifying these factors may well lead to an effective therapy for a commonly disabling disease.…”

“…The scars apparently prevented the development of psoriasis. This observation was considered supportive of the view that the dermo‐epidermal unit as a whole is involved in psoriasis 1 …”

Psoriasis responds to intralesional injections of alefacept and may predict systemic response to intramuscular alefacept: Interim results of a single-arm, open-label study

“…Specifically, electrodesiccation (16), deep shave (17), and mastectomy (18) have been described in the literature. It is suggested that destruction of the dermal papillae within the injured tissue prevented epidermal hyperplasia of psoriasis (16,19). Compared with our study, each of these cases involved much more extensive dermal injury.…”

Radiation dermatitis, burns, and recall phenomena: Meaningful instances of immunocompromised district

“…The occurrence of any skin disorder on a burn scar can be defined as an isocaumatopic response, from the Greek καũμα (meaning burn scar). The opposite is very rare, but it can occur (eg, psoriasis selectively sparing burn scars), 48 and represents an isocaumatopic nonresponse.…”