Dermal Dendrocytes in Dupuytren’s Disease: A Link Between the Skin and Pathogenesis?

Sugden, P.; Andrew, JG; Andrew, Sonja; Freemont, Anthony J.

doi:10.1016/0266-7681(93)90030-j

Cited by 14 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflammatory cells have been found at the periphery of Dupuytren nodules. 7,47 Our findings have confirmed this. These appear to produce a number of potent growth factors and cytokines 8,48,49 which are thought to stimulate Dupuytren's myofibroblasts to express their contractile fibrosing phenotype.…”

Section: Discussionsupporting

confidence: 87%

“…Clinical examples of fibrosis include systemic sclerosis, 38 renal interstitial fibrosis, 39,40 sarcoidosis, 41 idiopathic pulmonary fibrosis, 42,43 Reidel's thyroiditis, 44 retroperitoneal fibrosis 45,46 and Dupuytren's disease. 7,47 The presence of macrophages, eosinophils or lymphocytes has been initially demonstrated in all of these conditions. Many have shown impressive improvement after treatment with steroids.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dupuytren’s disease

Meek

McLellan

Crossan

1999

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

We studied tissue from 20 patients with Dupuytren's disease, four samples of normal palmar fascia from patients undergoing carpal tunnel decompression and tissue from ten patients who had received perinodular injections of depomedrone into the palm five days before operation. The distribution of VLA4, VCAM-1, CS1 fibronectin and TGF-ß was shown by immunohistochemistry using an alkaline phosphorylase method for light microscopy.In untreated Dupuytren's tissue CS1 fibronectin stained positively around the endothelial cells of blood vessels and also around the surrounding myofibroblasts, principally at the periphery of many of the active areas of the Dupuytren's nodule. VCAM-1 stained very positively for the endothelial cells of blood vessels surrounding and penetrating the areas of high nodular activity. VCAM-1 was more rarely expressed outside the blood vessels. VLA4 was expressed by inflammatory cells principally in and around the blood vessels expressing VCAM-1 and CS1 but also on some cells spreading into the nodule. TGF-ß stained positively around the inflammatory cells principally at the perivascular periphery of nodules. These cells often showed VLA4 expression and co-localised with areas of strong production of CS1 fibronectin.Normal palmar fascia contained only scanty amounts of CS1 fibronectin, almost no VCAM-1 and only an occasional cell staining positively for VLA4 or TGF-ß.In the steroid-treated group, VCAM-1 expression was downregulated in the endothelium of perinodular blood vessels and only occasional inflammatory cell expression remained. Expression of CS1 fibronectin was also much reduced but still occurred in the blood vessels and around the myofibroblast stroma. VLA4-expressing cells were also reduced in numbers. A similar but reduced distribution of production of TGF-ß was also noted.Our findings show that adherence of inflammatory cells to the endothelial wall and the extravasation into the periphery of the nodule may be affected by steroids, which reduce expression of VCAM-1 in vivo. This indicates that therapeutic intervention to prevent the recommencement of the chronic inflammatory process and subsequent fibrosis necessitating further surgery may be possible. J Bone Joint Surg [Br] 1999;81-B:732-8.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Dupuytren’s disease

Meek

McLellan

Crossan

1999

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

show abstract

“…Sugden et al 64 have also confirmed the presence of dermal dendrocytes (factor-XIIIa-positive cells) in Dupuytren's tissue. They suggested that this may represent an important link between the skin and the pathogenesis of Dupuytren's disease.…”

Section: Manipulation Of the Controls The Work On Interferon Bymentioning

confidence: 82%

Dupuytren’s Disease

Thurston¹

2003

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

“…Proponen que las células de Langerhans migran desde la epidermis al tejido de Dupuytren, posiblemente como respuesta a cambios locales de los niveles de citoquinas inflamatorias en el tejido. Estos hechos junto a otros trabajos como los de Sugden et al 98 sobre el incremento del número de dendrocitos dérmi-cos (células factor-XIIIa-positivo) y de células inflamatorias en el tejido de la ED sugieren una relación importante entre la piel y la patogénesis de la ED lo que apoya la teoría extrínseca.…”

Section: Origen De La Enfermedad De Dupuytrenunclassified

Untitled

2010

Rev Iberoam Cir Mano

View full text Add to dashboard Cite

INTRODUCCIÓNa enfermedad de Dupuytren (ED) es una enfermedad inflamatoria crónica del tejido conectivo, de etiología y patogenia no aclaradas, y de transmisión autosómica dominante. Se trata de una fibromatosis aponeurótica superficial, de tipo nodular, caracterizada por una proliferación incontrolada de fibro-miofibroblastos asociada a un aumento de la producción de factores de crecimiento, con abundante síntesis de matriz fibrilar extracelular. La causa que inicia y perpetúa la proliferación tisular es desconocida, pero diversos estudios han encontrado cambios clínicos, bioquímicos, epidemiológicos y morfológicos.Puede localizarse en diversas partes del organismo, pero la localización más frecuente es en la palma de la mano, en donde afecta a la dermis, a la aponeurosis palmar superficial y a la aponeurosis digital, pudiendo evolucionar hacia un acortamiento longitudinal de sus fibras, lo que ocasiona una flexión irreversible y una impotencia progresiva de los dedos afectos, alterando la función de la mano (Figura 1). EPIDEMIOLOGÍAExiste una significativa variabilidad geográ-fica, por lo que es difícil poder hacer una simple trasposición de datos de los resultados publicados. La prevalencia varía dependiendo del lugar en el que se tome la muestra de población, y es variable según el sexo y la edad de la población 1 , pues la incidencia es mayor en el hombre y aumenta con la edad 2 . La ED es una enfermedad de transmisión autosómica dominante con penetración variable 3,4 , con un origen en las razas celtas del norte de Europa. Las migraciones han diseminado la ED por todo el mundo, siendo más frecuente

show abstract

Dermal Dendrocytes in Dupuytren’s Disease: A Link Between the Skin and Pathogenesis?

Cited by 14 publications

References 10 publications

Dupuytren’s disease

Dupuytren’s disease

Dupuytren’s Disease

Untitled

Contact Info

Product

Resources

About