“…Contrary to the argumentation of Echeverria et al [10] and others [2,17,20,21,26], the result of the present study indicates that the EMD and corresponding deduction of HH-transformation only provide information about the regulation of the sinus arrhythmia when its parameters are properly tuned and ad hoc adjustments for artificial mode mixing are provided. According to the present result, this is shown to be difficult, even when the confidence interval procedure of Huang et al [16] is utilized, since the nonlinear origin of real RR series is not a priori known.…”