Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component.

Rassouli, Mohammad; Sambasivam, Hari; Azadi, Parastoo; Dell, Anne; Morris, H.R.; Nagpurkar, Arun; Mookerjea, Sailen; Murray, Robert K.

doi:10.1016/s0021-9258(19)50678-0

Cited by 33 publications

(1 citation statement)

References 28 publications

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“…The baseline CRP concentrations in mice was trace, ~7.5 μg/ml, which rise only twofold in the acute phase response ( 151 ), and have been reported to be a minor acute phase reactant in response to inflammatory stimuli ( 152 ). In healthy and pathogen-free rats, CRP ranges from 300–600 µg/ml ( 153 ). After injection of casein or croton oil, rising 3- to 4-fold in the acute phase response, it rose only up to about 900 µg/ml, indicating that it is a poor marker of acute inflammation.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

C-reactive protein: structure, function, regulation, and role in clinical diseases

Zhou,

Tang,

et al. 2024

Front. Immunol.

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C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to ligands like phosphocholine (PC). In humans and various other species, the plasma concentration of this protein is markedly elevated during inflammatory conditions, establishing it as a prototypical acute phase protein that plays a role in innate immune responses. This feature can also be used clinically to evaluate the severity of inflammation in the organism. Human CRP (huCRP) can exhibit contrasting biological functions due to conformational transitions, while CRP in various species retains conserved protective functions in vivo. The focus of this review will be on the structural traits of CRP, the regulation of its expression, activate complement, and its function in related diseases in vivo.

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Section: Conclusion and Prospectsmentioning

confidence: 99%