Derivation of Pasteurella multocida-free rabbit litters by enrofloxacin treatment

Suckow, Mark A.; Martin, Brent J.; Bowersock, T. L.; Douglas, Fred A.

doi:10.1016/0378-1135(96)00022-3

Cited by 18 publications

(9 citation statements)

References 8 publications

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“…For example, enrofloxacin (5 mg/kg bw.) given orally to rabbit does stopped transmission of Pasteurella to their young but failed to eliminate infection from the mother rabbits themselves [ 17 ]. Enrofloxacin given at 5 mg/kg im.…”

Section: Discussionmentioning

confidence: 99%

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

et al. 2014

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BackgroundPasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species.ResultsThirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1–3), (1–6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1–3), (1–6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics.ConclusionsIn our study, (1–3), (1–6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-014-0276-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

et al. 2014

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“…A P. multocida bacterin known as BunnyVac is currently licensed by the USDA and is intended to be effective in preventing death and limiting disease due to Pasteurella in rabbits. Furthermore, rabbits free of Pasteurella and other infectious agents can be obtained by enrofloxacin treatment and through cesarean section or hysterectomy rederivation (Pleasants, 1959;Suckow et al, 1996;Syukuda, 1979). com/).…”

Section: Pasteurellosismentioning

confidence: 99%

Biology and Diseases of Rabbits

Nowland

Brammer

García

et al. 2015

Laboratory Animal Medicine

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“…Antibiotic therapy may lead to resolution of clinical signs, but elimination of the organism is difficult. 61 , 83 Importantly, enrofloxacin may prevent the passage of P. multocida to the kits when the does are treated prior to kindling. 83 The client should be informed that it is very difficult to eliminate P. multocida from the patient and that recrudescence of clinical signs is likely.…”

Section: Treatment and Controlmentioning

confidence: 99%

Respiratory Diseases of Rodents and Rabbits

Langan

Lohmiller

Swing

et al. 2000

Veterinary Clinics of North America: Small Animal Practice

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This article is written to provide differential diagnostic help for the practitioner who suspects respiratory disease in rodents or rabbits. The authors are laboratory animal veterinarians who work with rodents and rabbits on a herd health basis but also have considerable experience dealing with individual mice, rats, guinea pigs, hamsters, gerbils, and rabbits. The article presents descriptions of the presentation, pathology, treatment, and control of the primary respiratory pathogens of these species, along with an explanation of conditions that may confuse the diagnostic efforts. The article also mentions reported pathogens of secondary importance and provides extensive references.

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Derivation of Pasteurella multocida-free rabbit litters by enrofloxacin treatment

Cited by 18 publications

References 8 publications

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

Biology and Diseases of Rabbits

Respiratory Diseases of Rodents and Rabbits

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