Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses

Ruscetti, Sandra K.; Cmarik, Joan L.

doi:10.1007/978-0-387-09581-3_3

Cited by 2 publications

(3 citation statements)

References 238 publications

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“…While some of these recombinant viruses were derived from naturally occurring active Emvs , others were produced after inoculating mice with laboratory strains of XRVs like Moloney or Friend MuLVs. In one unusual case, the oncogenic activity of the Friend MuLV-derived spleen focus forming virus, SFFV, was mapped to its env gene [ 164 , 165 ] that induces acute erythroblastosis by stimulating the erythropoietin receptor and by activating the signal transduction pathway linked to the protein tyrosine kinase sf-Stk [ 166 ].…”

Section: Origins Of Infectious Mulvsmentioning

confidence: 99%

Origins of the Endogenous and Infectious Laboratory Mouse Gammaretroviruses

Kozak¹

2014

Viruses

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Abstract:The mouse gammaretroviruses associated with leukemogenesis are found in the classical inbred mouse strains and in house mouse subspecies as infectious exogenous viruses (XRVs) and as endogenous retroviruses (ERVs) inserted into their host genomes. There are three major mouse leukemia virus (MuLV) subgroups in laboratory mice: ecotropic, xenotropic, and polytropic. These MuLV subgroups differ in host range, pathogenicity, receptor usage and subspecies of origin. The MuLV ERVs are recent acquisitions in the mouse genome as demonstrated by the presence of many full-length nondefective MuLV ERVs that produce XRVs, the segregation of these MuLV subgroups into different house mouse subspecies, and by the positional polymorphism of these loci among inbred strains and individual wild mice. While some ecotropic and xenotropic ERVs can produce XRVs directly, others, especially the pathogenic polytropic ERVs, do so only after recombinations that can involve all three ERV subgroups. Here, I describe individual MuLV ERVs found in the laboratory mice, their origins and geographic distribution in wild mouse subspecies, their varying ability to produce infectious virus and the biological consequences of this expression.

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Section: Origins Of Infectious Mulvsmentioning

confidence: 99%

Origins of the Endogenous and Infectious Laboratory Mouse Gammaretroviruses

Kozak¹

2014

Viruses

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“…Endogenous viral element (EVE) is a term used for such endogenous viruses and fragments (Holmes 2011). Retroviruses are common sources of EVEs, as host genome integration is essential to their replication (Herniou et al 1998;Ruscetti & Cmarik 2011;Goff 2013). Common in birds and mammals, vertically transmitted endogenous retroviruses (ERVs) may comprise 8% of all mammalian genomes (Weiss 2006;Huda et al 2008).…”

mentioning

confidence: 99%

“…Most become increasingly defective over time, cannot produce infectious virus and cause no negative effects. However, functional gene products implicated in cellular proliferation are sometimes transcribed and the replication and reintegration of functional retroviruses may cause neoplasia by insertional mutagenesis of proto‐oncogenes or tumour suppressor genes (Weiss ; Pedersen & Sorensen ; Ruscetti & Cmarik ). In fish, the first fully sequenced ERV was discovered in zebrafish Danio rerio (Hamilton).…”

mentioning

confidence: 99%