Deregulated expression of miR-107 inhibits metastasis of PDAC through inhibition PI3K/Akt signaling via caveolin-1 and PTEN

Xiong, Junjie; Wang, Dan; Wei, Ailin; Lu, Huimin; Tan, Chunlu; Li, Ang; Tang, Jie; Wang, Yichao; He, Sirong; Liu, Xuedong; Hu, Weiming

doi:10.1016/j.yexcr.2017.10.033

Cited by 57 publications

(41 citation statements)

References 23 publications

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“…This is the first study that shows the association of this microRNA with worsening of prognosis in patients with penile cancer, displaying histological grade 2 and 3, tumors larger than 2.0 cm, and staging III and IV. In previous studies, overexpression of mir-107 in colorectal and gastric cancers has been shown to suggest tumorigenic and metastatic potential (Kuasne et al, 2017;Xiong et al, 2017). Therefore, these data demonstrate the potential of miR-107 as a biomarker in the prognosis of penile cancer.…”

Section: Discussionsupporting

confidence: 68%

MIR-107, MIR-223-3P and MIR-21-5P Reveals Potential Biomarkers in Penile Cancer

Pinho¹,

Silva

Júnior³

et al. 2020

Asian Pac J Cancer Prev

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Section: Discussionsupporting

confidence: 68%

MIR-107, MIR-223-3P and MIR-21-5P Reveals Potential Biomarkers in Penile Cancer

Pinho¹,

Silva

Júnior³

et al. 2020

Asian Pac J Cancer Prev

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“…We also confirmed the function of miR-107 in promoting cell growth, metastasis, and invasion in vitro and in vivo. Previous studies have shown that miR-107 is involved in metastasis 25,26 and may serve as a prognostic risk factor in various cancers [27][28][29][30] . In view of these findings, the regulation of miR-107 by HOTAIRM1 may be a feasible strategy to inhibit PTC metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of target prediction using bioinformatics analyses, HOTAIRM1 may serve as a ceRNA for miR-107. Previous studies have demonstrated that miR-107 is engaged in numerous biological processes, including cell differentiation 22 , response to chemotherapy 23 , insulin resistance 24 , and metastasis 25,26 . Accumulating evidence has shown that high levels of miR-107 may be a risk factor in the prognostic monitoring of malignant diseases, such as gastric cancer 27 , oropharyngeal cancer 28 , colorectal cancer 29 , and breast cancer 30 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion

Chai

et al. 2020

Cell Death Dis

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The long noncoding RNA (lncRNA), HOX antisense intergenic RNA myeloid 1 (HOTAIRM1), has been shown to act as a tumor suppressor in various human cancers. However, the overall biological roles and clinical significance of HOTAIRM1 in papillary thyroid cancer (PTC) have not been investigated. In this study, we used quantitative reverse transcription PCR (qRT-PCR) to show that HOTAIRM1 was significantly downregulated in PTC tissues and low HOTAIRM1 expression levels were associated with lymph node metastasis and advanced TNM stage. We performed Cell Counting Kit-8, plate colony-formation, flow cytometric apoptosis, transwell, and scratch wound healing assays. Overexpression of HOTAIRM1 was found to inhibit PTC cell proliferation, invasion, and migration in vitro. Additionally, we identified miR-107 as a target of HOTAIRM1 using online bioinformatics tools. Dual-luciferase reporter gene and RNA immunoprecipitation assays were used to confirm that HOTAIRM1 acted as a competing endogenous RNA of miR-107. Furthermore, enhancement of miR-107 could potentially reverse the effects of HOTAIRM1 overexpression in vitro. Inhibition of miR-107 suppressed PTC cell proliferation, invasion, and migration in vitro. HOTAIRM1 overexpression and miR-107 inhibition impaired tumorigenesis in vivo in mouse xenografts. Bioinformatics prediction and a dual-luciferase reporter gene assay demonstrated the binding between miR-107 and the 3′-untranslated region of TDG. The results of qRT-PCR and western blotting assays suggested that HOTAIRM1 could regulate the expression of TDG in an miR-107meditated manner. In conclusion, we validated HOTAIRM1 as a novel tumor-suppressor lncRNA in PTC and proposed that the HOTAIRM1/miR-107/TDG axis may serve as a therapeutic target for PTC.

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“…Significantly, the mutations of PIK3CG in PDAC are also revealed [156]. EG-VEGF, TMEM158, miR-107, as well as LncRNA ABHD11-AS1, SNHG1 and AB209630 are involved in proliferation, apoptosis, metastasis or carcinogenesis of PDAC cells through PI3K/AKT pathway [162][163][164][165][166][167]. Plenty of clinical trials of PI3K inhibitors (BKM120, BYL719, GSK2636771, PKI-587, BEZ235 and LY3023414.…”

Section: Nct02240212mentioning

confidence: 99%

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

et al. 2020

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Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different cancers, which are closely related with tumorigenesis, proliferation, growth, apoptosis, invasion, metastasis, epithelial-mesenchymal transition, stem-like phenotype, immune microenvironment and drug resistance of cancer cells. In addition, we investigated the current clinical trials of inhibitors against PI3K/AKT pathway in cancers and found that the clinical efficacy of these inhibitors as monotherapy has so far been limited despite of the promising preclinical activity, which means combinations of targeted therapy may achieve better efficacies in cancers. In short, we hope to feature PI3K/ AKT pathway in cancers to the clinic and bring the new promising to patients for targeted therapies.

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Deregulated expression of miR-107 inhibits metastasis of PDAC through inhibition PI3K/Akt signaling via caveolin-1 and PTEN

Cited by 57 publications

References 23 publications

MIR-107, MIR-223-3P and MIR-21-5P Reveals Potential Biomarkers in Penile Cancer

MIR-107, MIR-223-3P and MIR-21-5P Reveals Potential Biomarkers in Penile Cancer

RETRACTED ARTICLE: The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

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