Der Verkalkungsvorgang bei der Entwicklung des Knochens

Freudenberg, E.; György, Paul

doi:10.1007/978-3-642-90617-6_3

Cited by 22 publications

(3 citation statements)

References 12 publications

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“…It did, however, have the great merit of drawing attention to an enzyme that is actually fundamental to calcification [9], while stressing the primary role of organic molecules in biological calcifications. This was also the important indication given by Freudenberg and György [10] in the same year, 1923. They noted that cartilage calcification occurs in vitro if the tissue is first treated with calcium chloride and then with phosphate, but not the reverse, and concluded that this was due to the binding of calcium to a colloid, with the subsequent binding of phosphate and formation of calcium-phosphoprotein complexes.…”

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confidence: 54%

The Mineralization of Bone and Its Analogies with Other Hard Tissues

Bonucci¹

2013

Advanced Topics on Crystal Growth

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Bone is one of the many biological tissues characterized by the still poorly defined process of mineralization, that is, by the deposition of inorganic substance in their organic matrix, and is one that, chiefly due to its important biological functions, but also because of its widespread presence in primates and its easy availability, has been investigated for hundred of years by thousand of investigators (see reviews by [1-3]). Its study, however, is a demanding task, because of the complexity and variability of the tissue-factors that derive mainly from differences in its histological types, biochemical composition, phases of maturation, and degree of mineralization (the terms 'mineralization', 'biomineralization', and 'calcification' are treated as equivalents in this paper; see Bonucci [2]). These differences, although recently emphasized [4-5], have not always received due recognition. In this connection, revealing indicative examples include, for instance, the differences between the compact, lamellar bone and spongy, woven bone [4], or between the dense rostrum bone of toothed whales [6] and the medullary bone of birds [7]. These differences may lead to incorrect interpretations of apparently contrasting results, but may also lead to new insights if they are recognized to derive from distinctive traits of tissues belonging to the same broad type, which is what they are. The concepts that follow, which chiefly focus on the local mechanism of matrix calcification, mainly refer to woven bone, which raises fewer technical issues than compact bone, but they are valid for, and can be extended to, all other types of bone and hard tissue. 2. Historical notes So much research has been carried out on bone mineralization that it is hard to provide an inclusive summary; moreover, research of this kind is often interlaced with that on other cal

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confidence: 54%

The Mineralization of Bone and Its Analogies with Other Hard Tissues

Bonucci¹

2013

Advanced Topics on Crystal Growth

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“…First, deJong (1926) observed that bone powder and mineral apatite give similar X-ray diffraction patterns. Second, Freudenberg and György (1923) observed that the cartilage matrix calcifies in vitro if first treated with calcium chloride and then with a phosphate mixture, but not vice versa; they therefore made the suggestion that the process first requires the binding of calcium to a tissue "colloid", and then phosphate binding, with the possible formation of calcium-phosphoprotein complexes. Second, Freudenberg and György (1923) observed that the cartilage matrix calcifies in vitro if first treated with calcium chloride and then with a phosphate mixture, but not vice versa; they therefore made the suggestion that the process first requires the binding of calcium to a tissue "colloid", and then phosphate binding, with the possible formation of calcium-phosphoprotein complexes.…”

Section: Before 1960mentioning

confidence: 99%

“…The observation by Freudenberg and György (1923) that the organic matrix of cartilage contains a calcium-binding "colloid" prompted various studies. Robison and Rosenheim (1934), while admitting that the amount of organic phosphates in calcifying matrix is too low to allow them to act as a substrate for alkaline phosphatase, and that the process occurs in extracellular sites, had already hypothesized that an enzymatic "second mechanism" may be involved.…”

Section: Before 1960mentioning

confidence: 99%