Der Vakuum-Extraktor

Malmstrom, T

doi:10.1007/bf00674230

Cited by 7 publications

(2 citation statements)

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“…More surprising is gastrin in the distal ileum. Previous studies have confined gastrin synthesis in the digestive tract to G-cells in the antroduodenal mucosa and -sporadically -in the proximal jejunum [22,23]. Antral G-cells synthesize five bioactive gastrins, of which gastrin-6 is completely sulfated, whereas gastrin-17, -34, and -71 are partly sulfated (for review, see [l]l).…”

Section: Discussionmentioning

confidence: 99%

Ileal expression of gastrin and cholecystokinin

Friis‐Hansen

Rehfeld

1994

FEBS Letters

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Antibodies against the common active site of cholecystokinin (CCK) and gastrin stain three endocrine celltypes in the gut: G-cells (that synthesize gastrin) I-cells (that synthesize CCK), and TG-cells (whose product is unknown). In order to examine whether TG-cells either process progastrin or proCCK in a specific manner, or express a novel gastrin-CCK related hormone, we studied the distal porcine ileum, which have far more TGthan G-and I-cells. Ileal CCK and gastrin mRNA corresponded to those of the antroduodenal mucosa. Gel, ion-exchange and reversed-phase chromatography monitored with sequence-specific immunoassays showed that the ileal mucosa on average contain 0.3 and 7.6 pmoYg progastrin and proCCK, respectively; 1.1 and 13.5 pmol/g glycine-extended intermediates; and 1.1 and 24.8 pmol/g of bioactive carboxyamidated gastrin and CCK, respectively. Gastrin was present only as non-sulfated gastrin-34, whereas CCK occurred in forms similar to those of the proximal intestine. Although ileal progastrin processing is tissue specific, the amounts of gastrin and CCK are too small to explain the TG-cells. Moreover, since the ileal extracts were without traces of other peptides having the C-terminus common to gastrin and CCK, the results suggest that TG-cells produce a peptide, which is only weakly related to gastrin and CCK.

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Section: Discussionmentioning

confidence: 99%

Ileal expression of gastrin and cholecystokinin

Friis‐Hansen

Rehfeld

1994

FEBS Letters

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“…Numerous associations and non-associations of HLA and RAS antigen have been reported in the medical literature. The association between the disease and HLAB12 was described by Lehner and colleagues (8) and Malmstr ِ◌m et al, (9), however it was not confirmed by other authors (10,11). In groups of patients of different ethnical origin, a significant association between HLA-DR2 and RAS was noticed (8,12).…”

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confidence: 88%

Genotyping of HLA-class-I and II by PCR-SSP of Patients with Recurrent Aphthous Stomatitis

Al-Ghurabei,

Saliah,

Al-Hassan

et al. 2012

JFacMedBagdad

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Background: Recurrent aphthous stomatitis is a common condition characterised by recurrent episodes of oral ulceration. Genetic factors have been implicated by numerous studies on the association of recurrent aphthous stomatitis and the genetically determined HLA subtypes.Objectives: Current study was established to shed light on the possible association of HLA class I and II alleles with recurrent aphthous stomatitis in Iraqi patients.Subjects and Methods: The study included 55 subjects: 30 recurrent aphthous stomatitis patients and 25 apparently healthy subjects as control. Polymerase chain reaction-specific sequence primers (PCR- SSP) assay was conducted to assess HLA- typing.Results: The present study showed a significant association of HLA-Cw*12:02:01-and HLADQB1* 02:01:01- alleles with recurrent aphthous stomatitis as compared with healthy control (P=0.041and P=0.028 respectively). Another interesting finding in this study was the significant low frequency of HLA-DQB1*05:01:01- allele in patients when compared with healthy control (P=0.036).Conclusion: These findings demonstrated that HLA-Cw*12:02:01- and HLA-DQB1*02:01:01-alleles may play a role in the etiology of the disease. Whereas HLA-DQB1*05:01:01-05 may confer protective effects against recurrent aphthous stomatitis.

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Volken Warner Walter Friedberg

Ludwig

1999

Die Reden

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Der Vakuum-Extraktor

Cited by 7 publications

References 1 publication

Ileal expression of gastrin and cholecystokinin

Ileal expression of gastrin and cholecystokinin

Genotyping of HLA-class-I and II by PCR-SSP of Patients with Recurrent Aphthous Stomatitis

Volken Warner Walter Friedberg

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