Der Stellenwert der Thymektomie ohne Thymom in der Therapie der Myasthenia gravis

Menghesha, Hruy; Schroeter, Michael; Doerr, Fabian; Schlachtenberger, Georg; Heldwein, M.; Chiapponi, Costanza; Wahlers, Thorsten; Bruns, Christiane; Hekmat, Khosro

doi:10.1007/s00104-021-01436-3

Cited by 3 publications

(4 citation statements)

References 63 publications

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“…Through a prolonged transsternal thymectomy, the surgeon makes a cut in the chest bone to gain access to the thymus. Although some surgical groups advocate for a more invasive technique through the chest, known as a transsternal thymectomy, other groups advocate for a less invasive approach through the neck, known as an extended transcervical thymectomy, claiming equivalent results [15] . Maximal thymectomy, in which both the transsternal and transcervical techniques are used on the same MG patient, is said to have better outcomes [16] .…”

Section: Thymectomymentioning

confidence: 99%

“…In comparison to the open (sternotomy) method, the risk of respiratory and cardiac problems (such as pneumonia, pleural effusion, or arrhythmias) is lower with the VATS approach. These difficulties necessitate individualized care, which in turn causes recuperation delays and extended hospital stays [15] .…”

Section: Trans-sternal Thymectomy Vs Video Assisted Thoracoscopic Sur...mentioning

confidence: 99%

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An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Desoky¹,

Emam²,

Ragab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Myasthenia gravis (MG) is a syndrome characterized by fatigue-and activity-induced improvements in skeletal muscular weakening. There is a wide range of possible involvement, including but not limited to the muscles of the eyes, face, oropharynx, trunk, and limbs. Once the patient's level of weakness has been managed to the point that surgery is possible, thymectomy is recommended. Preoperatively, patients are typically treated with mild doses of intravenous immunoglobulins as well as glucocorticoids. Objective: Review of the literature on thymectomy approaches among myasthenia graves' patients. Methods: We scoured medical journals and databases including PubMed, Google Scholar, and Science Direct for information on thymectomy and myasthenia graves. Between September 2006 and August 2022, however, only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references drawn from similar books. Documents written in languages other than English have been overlooked because of lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon not to constitute valid scientific investigation. Conclusion: It has been argued that a maximum thymectomy, in which both the transsternal and transcervical techniques are used on the same MG patient, yields superior results. After extensive transsternal thymectomy or video-assisted thoracoscopic thymectomy, half of patients with non-thymomatous MG had complete stable remissions at 6 years of follow-up.

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Section: Thymectomymentioning

confidence: 99%

Section: Trans-sternal Thymectomy Vs Video Assisted Thoracoscopic Sur...mentioning

confidence: 99%

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Desoky¹,

Emam²,

Ragab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…Because of the potential for surgery to worsen the MG symptoms, it should only be performed when the patient is neurologically balanced [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients showing signs of increased muscle weakness, bulbar manifestations, or respiratory impairment should benefit from plasmapheresis in the preoperative period [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis

Salahoru,

Grigorescu,

Hinganu

et al. 2024

JPM

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The thymus is a lymphoid organ involved in the differentiation of T cells, and has a central role in the physiopathogenesis of Myasthenia Gravis (MG). This connection is proved by a series of changes in the level of neuromuscular junctions, which leads to a decrease in the amplitude of the action potential in the post-synaptic membrane. Because of this, the presence of anti-cholinergic receptor antibodies (AChR), characteristic of MG, is found, which causes the progressive regression of the effect of acetylcholine at the level of neuromuscular junctions, with the appearance of muscle weakness. The thymectomy is a surgical variant of drug therapy administered to patients with MG. In the case of patients with nonthymomatous MG, thymectomy has become a therapeutic standard, despite the fact that there is no solid scientific evidence to explain its positive effect. Videothoracoscopic surgery or robotic surgery led to a decrease in the length of hospital stay for these patients. This paper aims to synthesize the information presented in the literature in order to create a background for the perspectives of thymectomy.

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Subxiphoid and subcostal arch versus unilateral video-assisted thoracic surgery approaches to thymectomy for myasthenia gravis

Huang

Han

et al. 2022

Surg Today

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Der Stellenwert der Thymektomie ohne Thymom in der Therapie der Myasthenia gravis

Cited by 3 publications

References 63 publications

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis

Subxiphoid and subcostal arch versus unilateral video-assisted thoracic surgery approaches to thymectomy for myasthenia gravis

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