Der Glucoseverbrauch des menschlichen Gehirns unter dem Einfluß intravenöser Infusionen von Glucose, Glucagon und Glucose-Insulin

Insulin increases glucose transfer across the blood-brain barrier in man.

“…Gottstein et al (27,28) made extensive investigations of the effect of insulin on the glucose uptake of the human brain and tried to avoid hypoglycemia by glucose infusion, although it was not possible to keep the blood-sugar constant and it increased by about 200%. They found that when the blood-sugar level was raised by glucose infusion, brain glucose uptake increased, but the increase was much more pronounced when insulin was infused together with the glucose.…”

Brain Metabolism during Fasting*

“…In addition, Kety et al (35) noted decreased respiratory quotients in patients in diabetic ketoacidosis; but direct utilization of keto acids has not been found in this condition (3) or in fat-fed animals (36). G6ttstein et al also observed decreased respiratory quotients in patients with cerebral arteriosclerosis (37). Additional indirect evidence for a novel carboxylation reaction which would result in a low quotient has been Sacks' studies on glucose-14C oxidation in human brain whereby only 50%o of glucose-carbon that is oxidized is recovered in effluent CO2 and HCO:, (38).…”

Glucose metabolism in children during the first day after burn injury.

“…The highest blood glucose concentration measured, 16mmol/I blood above the control value, could be accounted for by a release of only 90mmol/kg liver. The brain would require a further supply equivalent to 7-lOmmol/h.kg liver (Gottstein et al, 1965)). …”