26 plant growth regulators including herbicides were investigated in their effect on the multiplication of Escherichia coli, Bacillus subtilis, and the blue-green alga Plectonema boryanum as well as the RNA phages M 12 and QB and the DNA phages A, @ 105, and LPP-1 employing the agar diffusion method. Nearly all of the compounds inhibited and/or stimulated one or some of the prokaryotes tested. The most frequent and strongest effects occurred in PI. boryanurn, the least effects in E. coli. The multiplication of phages was also influenced by plant growth regulators leading to increase, decrease or non-appearance of plaques. The investigations with the temperate phages rZ and @ 105 suggested part of the compounds to be able to interfere with the process of lysogenization. The results are discussed comparatively involving correspondent findings referred to in literature.