Der Einfluß körperlichen Trainings auf den Kollateralkreislauf des Herzens

Schäper, Wolfgang; Flameng, Willem; Snoeckx, L. H. E. H.; Jageneau, A

doi:10.1007/978-3-642-72303-2_10

Cited by 16 publications

(6 citation statements)

References 9 publications

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“…Schaper et al (3), in 1967, described the predilection sites of developed collaterals in the pig (the papillary muscles) and measured the peripheral coronary pressures in pigs and dogs. In a later study (18) these authors compared the peripheral coronary pressures in the two species and found them to be lower in pigs. Prolonged physical exercise increased PCP in the pig but not in the dog (18).…”

Section: Literature Reviewmentioning

confidence: 94%

Microvascular and collateral adaptation in swine hearts following progressive coronary artery stenosis

Görge¹,

Schmidt²,

Ito³

et al. 1989

Basic Res Cardiol

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We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts were explanted and perfused in Langendorff-fashion with leucocyte-filtered pig blood. Maximal coronary vasodilation was induced with adenosine and global (electromagnetic), and regional (tracer microspheres) blood flow was measured at 40, 60, 80, and 100 mm Hg of perfusion pressure. At 4 weeks after occluder implantation maximal left circumflex collateral blood flow was about 20% of normal maximal flow. Collateral flow rose to 60% of maximal normal flow between 4 and 8 weeks and did not improve further with longer time intervals. In contrast to the canine heart numerous small vessels develop in response to ischemia in the pig heart. These vessels develop throughout the entire risk region with a slight preference for the subendocardium. They appear on tomographic angiograms as a dense "blush". The study of the relationship between peripheral coronary pressure vs collateral flow showed a relationship much steeper than that of normal maximal flow vs aortic perfusion pressure which indicates that the minimal resistance of the risk region was decreased as part of the mechanism to ensure adequate blood supply in a situation of progressive coronary narrowing.

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Section: Literature Reviewmentioning

confidence: 94%

Microvascular and collateral adaptation in swine hearts following progressive coronary artery stenosis

Görge¹,

Schmidt²,

Ito³

et al. 1989

Basic Res Cardiol

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“…There is no doubt that a training program will usually improve exercise tolerance even in patients with coro nary heart disease, but repeated studies have confirmed that most of this improvement is due to changes in peripheral efficiency [4], The excellent work of Schaper et al [5] has been confirmed by others [6] who have demonstrated that exercise does not improve collateral flow in dogs contrary to the long held view following Eckstein's [7] earlier experiments. There is also no data to demonstrate exercise induced collaterals in CAD pa tients.…”

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confidence: 38%

Is Exercise Harmful in Ischemic Heart Disease?

Ellestad¹

1987

Am J Noninvas Cardiol

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Advances in the clinical understanding of myocardial ischemia have raised questions about the prescription of exercise in patients with coronary narrowing. Significant numbers of subjects engaged in strenuous exercise die during the event, usually of coronary artery disease. Recent data indicates that ST depression in patients with coronary disease is invariably due to ischemia. Many patients with this problem exercise to the extent that they have prolonged ischemia often without pain, on the recommendation of their physicians. Because this ischemia increases the risk of sudden death and may also cause myocardial cell death in the absence of clinical infarction, we should reconsider some of the recommendations for exercise now in vogue for patients with coronary heart disease.

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“…So far the pig has been scarcely used in the study of the effects of endurance exercise on cardiac performance (19,(26)(27)(28)31). This study demonstrates that domestic swine are very suitable for such investigations, as the exercise sessions were uneventful and the increases in maximum exercise capacity, left ventricular mass and end-diastolic myocardial wall thickness are similar to those for man and dog.…”

Section: Discussionmentioning

confidence: 65%

Decreased incidence of ventricular fibrillation after an acute coronary artery ligation in exercised pigs

Scheffer

Verdouw

1983

Basic Res Cardiol

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Evidence has been presented that regular physical activity may be associated with a decreased incidence of sudden cardiac death. It has been suggested that self-selection of those engaging in regular exercise rather than the physical activity itself is a major factor in explaining these results. We therefore studied the effects of a two-month exercise program on the incidence of ventricular fibrillation after an acute ligation of the left anterior descending (LAD) coronary artery in domestic Yorkshire pigs. At the end of the exercise program, the exercised group (EG, n = 17) had a lower heart rate (10%), a 5 times higher maximum exercise capacity, a 10% larger left ventricular mass and a thicker myocardial wall during end-diastole than a sedentary group (SG, n = 13). After the animals were anesthetized, the LAD artery was occluded at one third of its distal end. Ventricular fibrillation (VF) occurred in 92% of the SG (12 out of 13) against only 30% of the EG (5 out of 17) within 1 hour after occlusion. Percentage of the area at risk was the same (9-10% of total left ventricular mass) in both the EG and SG. Transmural myocardial perfusion after coronary artery ligation was slightly larger in EG than in SG (30 vs 21 ml . min-1 . 100 g-1, p less than 0.05). Although the improvement in perfusion of the ischemic zone of the EG may have contributed to the reduced occurrence of ventricular fibrillation, other mechanisms cannot be excluded.

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Der Einfluß körperlichen Trainings auf den Kollateralkreislauf des Herzens

Cited by 16 publications

References 9 publications

Microvascular and collateral adaptation in swine hearts following progressive coronary artery stenosis

Microvascular and collateral adaptation in swine hearts following progressive coronary artery stenosis

Is Exercise Harmful in Ischemic Heart Disease?

Decreased incidence of ventricular fibrillation after an acute coronary artery ligation in exercised pigs

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