Decreased incidence of ventricular fibrillation after an acute coronary artery ligation in exercised pigs

Scheffer, M; Verdouw, P. D.

doi:10.1007/bf01907439

Cited by 23 publications

(11 citation statements)

References 38 publications

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“…We also noticed that falipamil and alinidine both decreased LVdP/dtmax dose dependently when heart rate was fixed by atrial pacing and that the magnitude of these changes were very similar during pacing and normal sinus rhythm [17,19]. This last observation is most likely explained by the observation that, at least in anesthetized pigs, LVdP/dtmax is not very sensitive to changes in heart rate in the range of 100-150 beats/min [20]. In three preliminary experiments in anesthetized pigs, we have observed that UL-FS 49 did not significantly decrease LVdP/ dtmax, when heart rate was kept constant by atrial pacing at 110 bpm.…”

Section: Discussionmentioning

confidence: 69%

The selective bradycardic effects of zatebradine (UL-FS 49) do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion

Woerkens

Giessen

Verdouw

1992

Cardiovasc Drug Ther

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This study was designed to test whether the selective bradycardic effects of zatebradine (UL-FS 49) were altered in the setting of chronic mild left ventricular dysfunction secondary to a myocardial infarction. We therefore administered four doses of UL-FS 49 at 15-min intervals (cumulative doses of 10, 30, 100, and 300 micrograms/kg) to eight normal conscious pigs and to seven pigs in which the left circumflex coronary artery was occluded 3 weeks previously. Left ventricular dysfunction in this second group of animals was manifested by an increase in left ventricular end-diastolic pressure (LVEDP, 11 +/- 2 mmHg vs. 7 +/- 1 mmHg, respectively; p less than 0.05) and a decrease in LVdP/dtmax (3020 +/- 210 mmHg vs. 3720 +/- 210 mmHg, respectively; p less than 0.05). The results showed that UL-FS 49 was equally effective in reducing heart rate in both groups of animals [from 126 +/- 4 to 95 +/- 2 beats/min and from 140 +/- 5 to 98 +/- 6 beats/min for the normal animals and for the animals with a chronic myocardial infarction (MI), respectively]. The duration of left ventricular systole was not affected, but the duration of diastole was prolonged from 290 +/- 10 msec to 420 +/- 20 msec in the normal animals and from 250 +/- 10 msec to 430 +/- 30 msec in the animals with MI (both p less than 0.05). Up to 100 micrograms/kg UL-FS 49 did not affect arterial blood pressure, whereas LVdP/dtmax and cardiac output decreased by less than 10% in either group.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 69%

The selective bradycardic effects of zatebradine (UL-FS 49) do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion

Woerkens

Giessen

Verdouw

1992

Cardiovasc Drug Ther

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“…The question therefore remains to what extent the increase in LVdP/dtmo, induced by these pyridazinone derivatives reflects true positive inotropy. In anaesthetized pigs we have shown that increasing heart rate, by atrial pacing, from 100 beats min-' to 160 beats min-' has no effect on LVdPldtmax (Scheffer & Verdouw, 1983). Although we have no such data in the conscious animal, it appears unlikely that LVdP/dt,, would more than double when heart rate increases only by 30%.…”

Section: Discussionmentioning

confidence: 85%

Systemic haemodynamic actions of pimobendan (UD‐CG 115 BS) and its O‐demethylmetabolite UD‐CG 212 Cl in the conscious pig

Duncker

Hartog

Levinský

et al. 1987

British J Pharmacology

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1 The cardiovascular effects of the pyridazinone-derivatives pimobendan and its O-demethylmetabolite UD-CG 212 Cl (2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl) benzimidazole HCI) were studied in conscious pigs, employing consecutive intravenous 10 min infusions of 10, 25, 50 and 100 pg kg-'min-' and 2, 4 and 8 pg kg-'min-' respectively. 2 Pimobendan caused dose-dependent increases in LVdPIdtmaX (up to 115%) and heart rate (up to 30%), while cardiac output was slightly elevated (up to 15%) and stroke volume decreased by 12%.Left ventricular end-diastolic pressure decreased in a dose-related manner from 8.7 ± 1.0 mmHg to 2.7 ± 1.7 mmHg. Mean arterial blood pressure was not significantly affected because systemic vascular resistance decreased dose-dependently up to 15%.3 After P-adrenoceptor blockade, the pimobendan-induced increases in heart rate and cardiac output were attenuated and the increase in LVdP/dtn,,X almost abolished. The responses of left ventricular enddiastolic and mean arterial blood pressure, systemic vascular resistance and stroke volume were not modified.4 UD-CG 212 Cl caused dose-related increases in LVdP/dt,,mx (up to 100%) and heart rate (up to 25%). Cardiac output was minimally elevated (up to 8%) as stroke volume decreased dosedependently up to 15%. As systemic vascular resistance decreased up to 12%, mean arterial blood pressure was slightly reduced (5%). Left ventricular end-diastolic blood pressure decreased dosedependently from 9.0 ± 0.8 mmHg to 3.8 ± 1.3 mmHg.5 After P-adrenoceptor blockade, the UD-CG 212 Cl-induced increases in heart rate and LVdP/dtmax were attenuated and almost abolished and amounted up to 15% and 20%, respectively. The responses of the other systemic haemodynamic parameters were not significantly modified. 6 We conclude that pimobendan and UD-CG 212 Cl are compounds with marked positive inotropic and venodilator properties in the conscious pig. The attenuation of the inotropic effects by pretreatment with propranolol strongly suggests that, in the conscious pig, the P-adrenergic system is significantly involved in the positive inotropic actions. The lack of effect of P-adrenoceptor blockade on the vasodilator responses to both compounds suggest a mechanism not related to fi-adrenergic activity. IntroductionThe pyridazinone-derivative pimobendan (UD-

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“…Concerning the first point, selection of pigs for physiological characteristics such as cardiovascular capacity rather than for production only is one option. With regard to the second point, it is known that also in pigs cardiovascular development is positively influenced by physical exercise (28). In the current system, pigs do not get much exercise, most of their time is devoted to either sleeping or eating.…”

Section: Pathophysiology and Disease Prevention In Pigsmentioning

confidence: 99%

A review of porcine pathophysiology: A different approach to disease

Niewold¹,

Essen²,

Nabuurs³

et al. 2000

Veterinary Quarterly

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Diseases are often thought to result from a single cause. Although this is sometimes the case, e.g. with a highly virulent infection such as Classical Swine Fever (CSF), more often clinical disease in swine herds results from multiple predisposing factors. This is especially true in modern intensive pig husbandry, in which the role of highly infectious diseases is limited to (nonetheless devastating) outbreaks. More important nowadays are diseases, although associated with an agent, without a clear pathogenesis. The emphasis in disease control thus far has been on treatment, eradication and prevention. This has been achieved by focusing attention on husbandry factors, such as climate, housing, hygiene, management, and nutrition. Although this approach has been successful for a number of diseases, several health problems are persistent. There are strong indications that in the latter, intrinsic animal factors are important. Successful handling of these problems requires knowledge of the (patho)physiology of the pig. In this article, several characteristics of pig physiology associated with the occurrence of disease are described. It appears that the modern (fattening) pig is exceptional among other animal species in that its cardiovascular system is mismatched to its body weight. It is argued that this particular disposition causes relatively minor disturbances to have major consequences in the pig. This concept of pig physiology is central to the understanding of the hitherto poorly understood pathogenesis of several diseases, such as oedema disease.

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Decreased incidence of ventricular fibrillation after an acute coronary artery ligation in exercised pigs

Cited by 23 publications

References 38 publications

The selective bradycardic effects of zatebradine (UL-FS 49) do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion

The selective bradycardic effects of zatebradine (UL-FS 49) do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion

Systemic haemodynamic actions of pimobendan (UD‐CG 115 BS) and its O‐demethylmetabolite UD‐CG 212 Cl in the conscious pig

A review of porcine pathophysiology: A different approach to disease

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