“…Since one of the m ajor func tions of the skin is the repression of the water vapour loss from the organism, we feel th at the m easurement of the w ater vapour loss through the skin may be used as a param eter for the intactness of the skin, or for the damage caused by prim ary toxic substances. As Szakall has shown in his last posthum e publication [5], a relationship may exist between the increased w ater vapour loss of the skin and the increased w ater perm eability from outside through the epidermis into the dermis. Thus, water-soluble substances damaging the waterbarrier zone and leading to an increased water vapour loss from the damaged skin, may penetrate more easily and cause toxic derm atitis.…”