Der Anteil von Histamin an der anaphylaktischen und der durch einen chemischen Histaminfreisetzer hervorgerufenen vasculären Hautreaktion

Alberty, J; Takkunen, R

doi:10.1159/000228386

Cited by 23 publications

(3 citation statements)

References 4 publications

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“…Several workers, using the guinea-pig as the test species, have found Hl-receptor antagonists to be far more effective in reducing the permeability response produced by exogenous histamine than by compound 48/80 and cutaneous anaphylaxis (Miles & Miles, 1952;Alberty & Takkunen, 1957;Craig & Wilhelm, 1963). These results suggest that endogenous histamine may not play a major role in mediating inflammatory responses caused by mast cell degranulation.…”

Section: Discussionmentioning

confidence: 99%

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

Owen¹,

Poy²,

Woodward³

et al. 1980

British J Pharmacology

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1 The role of histamine Hl-and H2-receptors in mediating the cutaneous inflammatory response produced by exogenous histamine and the release of endogenous histamine from mast cells has been investigated by a method which permits simultaneous, quantitative measurement of vasodilatation, vascular permeability and oedema formation.2 Histamine and the selective H1-receptor agonist, 2-(2-aminoethyl) pyridine, both produced vasodilatation, increased vascular permeability and oedema formation whereas the selective H2-receptor agonist, dimaprit, produced only vasodilatation. 3 Mepyramine and cimetidine both reduced the vasodilatation response to histamine, the combination of antagonists being superior to either antagonist alone. Mepyramine (but not cimetidine) virtually abolished extravascular albumin accumulation and oedema formation. 4 Mepyramine and cimetidine both reduced the vasodilatation response produced by active cutaneous anaphylaxis and compound 48/80. However, mepyramine was less effective in reducing the vascular permeability response to mast cell degranulation than to histamine. 5 In conclusion, the vasodilator response to histamine is mediated by both H1-and H2-receptors; the permeability response to histamine is mediated solely by HI-receptors. A combination of H1-and H2-receptor antagonists appears to be more effective than either antagonist alone in reducing cutaneous inflammatory reactions involving histamine.

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Section: Discussionmentioning

confidence: 99%

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

Owen¹,

Poy²,

Woodward³

et al. 1980

British J Pharmacology

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“…In a previous study on cutaneous anaphylaxis in the guinea pig ear [17], the same doses of mepyramine and cimetidine produced a comparable displacement of the vasopermeability dose-response curve, potency ratio 0.132 (0.023-0.605), to that obtained in these substance P experiments. The specific doses of mepyramine and cimetidine used are capable of virtually abolishing histamine-induced cutaneous inflammation [17,18,24], and the antihistamineresistant microvascular permeability component associated with intradermal substance P is a phenomenon frequently encountered in cutaneous mast cell degranulation [17,[25][26][27]. However, the evidence provided herein for mast cell involvement is indirect, and the existence of some direct vasopermeability activity cannot be totally excluded.…”

Section: Discussionmentioning

confidence: 99%

Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P

et al. 1985

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The cutaneous microvascular changes produced by intradermal substance P were quantitatively evaluated in both substance P-injected and contralateral, saline-injected guinea pig ears. Substance P evoked a dose-dependent increase in cutaneous microvascular permeability in both treated and untreated ears which was reduced, but not abolished, by a mepyramine-cimetidine combination. This indicates that the local effect of substance P on microvascular permeability and the effect on the contralateral ear (presumably the result of systemic substance P absorption) are both partially mediated by histamine. A cutaneous vasodilator response was also observed in substance P treated and contralateral ears, but a bell-shaped dose-response relationship was apparent. Unlike microvascular permeability, pretreatment with mepyramine and cimetidine failed to consistently attenuate the vasodilator response to substance P. Thus, a direct cutaneous vasodilator effect appears to predominate in both substance P-injected and saline-injected ears.

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“…To avoid such an interaction a time interval of about 3 hours between ingestion of iron and tetracyclines is necessary (121). Alberty (122,123) has explored the mechanisms of ana phylactic and allergic reactions in different organs, the role of released his tamine in these mechanisms, and the inhibition of its effect. The work of Maenpaa, Raivio and associates (124,125) has explained the dose-depen dence and specificity of the D-fructose-induced depletion of liver adenine nucleotides.…”

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confidence: 99%

History and Highlights of Finnish Pharmacology

Vartiainen¹

1972

Annu. Rev. Pharmacol.

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In 1640, when Finland was part of the Kingdom of Sweden, a university was founded in the city of Turku, then the capital of Finland. After Czar Alexander I of Russia, acting on his pact with Napoleon, had seized the country in 1808-09 and annexed it as an autonomous grand duchy to the Rus sian empire, he moved the capital of Finland to Helsinki in 1812. A devas tating fire in Turku in 1827 prompted the transfer of Finland's only univer sity to Helsinki. Other universities were founded after Finland had declared itself an independent state on December 6, 1917.In 1844 a professorship in pharmacy and pharmacology was established in the faculty of medicine of the University of Helsinki. The fi rst holder of the chair, F. J. von Becker, M.D., was appointed in 1854. He had studied pharmacy and pharmacology in G6ttingen, Leipzig, and Vienna, and his re search work covered, among other subjects, the metabolism of carbohydrates and the physiology of digestion, and also the structure, function, and dis eases of the eye and their treatment. Dr. von Becker studied surgery and ophthalmology in Germany and France, and under his influence a professor ship in ophthalmology was founded in the University of Helsinki in 1871. He held the chair from its founding up to his retirement in 1885. As his successor in the professorship, which by that time had been changed to that of physiological chemistry and pharmacology, was ap pointed E. E. Sundvik, M.D., who had carried on further studies in Strass burg and Berlin. Sundvik's research work dealt with, among other subjects, conjugation processes, uric acid metabolism, and many other problems in the physiological chemistry of the living organism. He also was the head of the pharmaceutical laboratory, gave instruction both to students of phar macy and to those of medicine, and was the principal collaborator in the preparation of Pharmacopoea Fennica IV.Finland's autonomy included also its own pharmacopeia.

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Der Anteil von Histamin an der anaphylaktischen und der durch einen chemischen Histaminfreisetzer hervorgerufenen vasculären Hautreaktion

Cited by 23 publications

References 4 publications

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P

History and Highlights of Finnish Pharmacology

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Der Anteil von Histamin an der anaphylaktischen und der durch einen chemischen Histaminfreisetzer hervorgerufenen vasculären Hautreaktion

Cited by 23 publications

References 4 publications

EVALUATION OF THE ROLE OF HISTAMINE H1AND H2‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

EVALUATION OF THE ROLE OF HISTAMINE H1AND H2‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P

History and Highlights of Finnish Pharmacology

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EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION

EVALUATION OF THE ROLE OF HISTAMINE H₁AND H₂‐RECEPTORS IN CUTANEOUS INFLAMMATION IN THE GUINEA‐PIG PRODUCED BY HISTAMINE AND MAST CELL DEGRANULATION