Depressive tendency in children with growth hormone deficiency

Abe, Shinpei; Okumura, Akihisa; Mukae, Tomoaki; Nakazawa, Tomoyuki; Niijima, Shinichi; Yamashiro, Yuichiro; Shimizu, Toshiaki

doi:10.1111/j.1440-1754.2009.01586.x

Cited by 32 publications

(24 citation statements)

References 17 publications

(21 reference statements)

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“…Our finding that GH treatment improved QoL is also consistent with the findings of similar studies conducted in the US (10) and Japan (14) in which QoL was improved after GH treatment as determined using the parent-rated CBCL and the child-rated Depression Self-Rating Scale for Children, respectively. In contrast, Sheppard et al .…”

Section: Discussionsupporting

confidence: 91%

“…Our findings, and those reported by Abe et al . (14), suggest that GH treatment can enhance the QoL of Japanese children with GHD.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Abe et al . reported that Japanese children with GHD have depressive tendencies and that GH treatment ameliorates these tendencies (14). To our knowledge, no study has described the effects of GH treatment on QoL in Japanese children with GHD as determined using the CBCL or Youth‑Self Report Form (YSR).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study

Tanaka

Hasegawa

Ozono

et al. 2014

Clin Pediatr Endocrinol

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The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = –3.42 [11.21]) and ISS (n = 129, mean change = –4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = –9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = –0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

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Section: Discussionsupporting

confidence: 91%

“…Our findings, and those reported by Abe et al . (14), suggest that GH treatment can enhance the QoL of Japanese children with GHD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study

Tanaka

Hasegawa

Ozono

et al. 2014

Clin Pediatr Endocrinol

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“…Our finding that the levels of depression in short children reduced after 3 months on GH treatment is in accordance with a recent study in peripubertal children with isolated GHD [36]. However, we found a gender difference for depression scores.…”

Section: Discussionsupporting

confidence: 75%

Improvements in Behaviour and Self-Esteem following Growth Hormone Treatment in Short Prepubertal Children

et al. 2011

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Background/Aims: To evaluate effects of growth hormone (GH) treatment on behaviour and psychosocial characteristics in short-stature children. Methods: 99 referred prepubertal non-familiar short-stature children (32 GH deficiency; 67 idiopathic short stature) aged 3–11 years, randomized to fixed or individual GH doses and their parents completed questionnaires (Child Behaviour Checklist, Birleson Depression Self-Report Scale, Abbreviated Parent-Teacher Questionnaire, I Think I Am, Well-Being Visual-Analogue Scales for Short-Stature Children) at baseline (BL) and after 3, 12, and 24 months. Results: At BL, children showed higher levels of internalizing behaviour (p < 0.001), lower levels of externalizing behaviour (p < 0.006) and self-esteem (p < 0.001) compared to reference values. During GH treatment, behavioural measures (p < 0.001) and depression (p < 0.01) changed towards the mean of the population within the first 3 months and remained improved to 24 months. Self-esteem improved at all time points (p < 0.001), and in all subgroups, as did well-being dimensions stability and mood (p < 0.05). Multiple regression analysis showed that greater improvements were related to lower BL value, height gain, higher maximal GH value, being older, and being male. Conclusion: On GH treatment, prepubertal short children significantly improved on behavioural, depression, and psychosocial evaluations over a 2-year period of GH treatment. Most change occurred within the first 3 months, which highlights this short period as important not only for growth and metabolic changes but also for behaviour and psychosocial improvements following GH treatment.

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“…Abdominal adiposity is related to the production of GH, and its decrease influences not only obesity (30) but also a depressive state (1). Furthermore, a decrease of GH secretion is reported to be associated with metabolic syndrome and type 2 diabetes (7,14,31).…”

Section: Ham-d Scalementioning

confidence: 99%

The “Senobi” breathing exercise ameliorates depression in obese women through up-regulation of sympathetic nerve activity and hormone secretion

2011

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Obese individuals have an increased risk of developing depression. This study aimed to determine whether the "Senobi" breathing exercise (SBE), a stretching-breathing exercise that we have established, could relieve depression, especially in obese women. Forty premenopausal women, aged 40 to 49 years, participated in the present study. Twenty were healthy, and the other 20 were obese (body mass index > 25 and body fat > 30%) and in a depressive state (OWD). Sympathetic nerve activity determined by analyzing heart rate variability, and the hormone levels in the urine were investigated before and 30 min after one minute of SBE. The relative proportion of sympathetic nerve activity among healthy women in the daytime was 79.2 ± 2.3%, whereas that in OWD group was 30.4 ± 1.9%. After one minute of SBE, significant up-regulation of sympathetic nerve activity and increased concentrations of catecholamines, estradiol, and growth hormone (all P values < 0.001) were observed in OWD group. After 30 days of SBE, the sympathetic nerve activity and hormone levels had recovered in OWD group, and the depressive state, as evaluated by the Hamilton Depression Scale, had ameliorated. The "Senobi" breathing exercise was found to be effective for amelioration of depression in obese women possibly through up-regulation of sympathetic nerve activity and hormone secretion.

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Depressive tendency in children with growth hormone deficiency

Cited by 32 publications

References 17 publications

Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study

Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study

Improvements in Behaviour and Self-Esteem following Growth Hormone Treatment in Short Prepubertal Children

The “Senobi” breathing exercise ameliorates depression in obese women through up-regulation of sympathetic nerve activity and hormone secretion

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